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FLASH GENE
Symbol ELF1 contributors: mct/ - updated : 09-05-2018
HGNC name E74-like factor 1 (ets domain transcription factor)
HGNC id 3316
Location 13q14.11      Physical location : 41.506.055 - 41.593.508
Synonym symbol(s) EFTUD1, RIA1
DNA
TYPE functioning gene
STRUCTURE 87.45 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC390397 13 similar to NTF2-related export protein 1 (p15 protein) LHFP 13q12 lipoma HMGIC fusion partner COG6 13q13.3 component of oligomeric golgi complex 6 FOXO1A 13q14.1 forkhead box O1A (rhabdomyosarcoma) MRPS31 13q13.2 mitochondrial ribosomal protein S31 SLC25A15 13q14 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 HCP34 13q14.11 cytochrome c, somatic pseudogene ELF1 13q13 E74-like factor 1 (ets domain transcription factor) WBP4 13q13.3 WW domain binding protein 4 (formin binding protein 21) KBTBD6 13q13.3 kelch repeat and BTB (POZ) domain containing 6 LOC390398 13 similar to calmodulin 1; Calmodulin 1 (phosphorylase kinase, delta) KBTBD7 13q13.3 kelch repeat and BTB (POZ) domain containing 7 MTRF1 13q14.1-q14.3 mitochondrial translational release factor 1 FLJ22054 13q13.3 hypothetical protein FLJ22054 LOC387922 13 similar to tubulin, beta 5 LOC390399 13 similar to olfactory receptor MOR145-1 OR7E37P 13q14.12 olfactory receptor, family 7, subfamily E, member 37 pseudogene RGC32 13q13.3 response gene to complement 32 KIAA0564 13q13.3 KIAA0564 protein DGKH 13q13.3 diacylglycerol kinase, eta MAPK6PS3 13q14.13 diacylglycerol kinase, eta LOC341651 13q13.3 similar to bA215B13.2 (fumarate hydratase (FH) pseudogene) AKAP11 13q14.3 a kinase (PRKA) anchor protein 11 FABP3P2 13q13-q14 fatty acid binding protein 3, pseudogene 2 TNFSF11 13q14 tumor necrosis factor (ligand) superfamily, member 11
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3760 - 619 - 1998 9524226
8 - 3543 - 595 - 1998 9524226
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage lymphoid and myeloid cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal A transactivation domain
  • a central AT hook domain
  • a C terminal ETS DNA binding protein
  • HOMOLOGY
    interspecies homolog to C.elegans c30b5.1
    Homologene
    FAMILY
  • ETS family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in the transcriptional regulation of several hematopoietic cell genes
  • regulating vascular-specific gene expression during blood vessel development
  • transcriptional regulator of TEK
  • required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression
  • involved in transcriptional activation of PYGO2
  • involved in T cell development and function
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to both Ets binding sites (EBS1,EBS2) of IL2 enhancer
    RNA
    small molecule
    protein
  • binding to RB1 in resting normal T cells
  • in the nucleus, binds to the promoter of the TCR zeta gene and promotes its transcription in Jurkat and fresh T cells
  • interacting with GATA3
  • interaction with LAT (overexpression of ELF1 augments LAT promoter activity)
  • an important positive regulator of MEIS1 expression
  • FLI1, ELF1, and GABPA regulate PF4 gene expression through the -51 ETS site in megakaryocytes and implicate the differentiation stage-specific regulation of PF4 gene expression by multiple ETS factors
  • ELF1 binds an important duplicated GGAA cis-acting element at the OAS1 promoter and in cooperation with RB1 and SP1 recruitment contributes to regulation in response to IFN stimulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    with decreased TCR zeta chain gene expression in patients with systemic lupus erythematosus
    Susceptibility to systemic lupus erythematosus
    Variant & Polymorphism other polymorphisms increasing the risk of systemic lupus erythematosus
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS