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FLASH GENE
Symbol ELAVL4 contributors: mct/npt - updated : 31-08-2016
HGNC name ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
HGNC id 3315
Location 1p33      Physical location : 50.513.685 - 50.667.540
Synonym name
  • paraneoplastic encephalomyelitis antigen HuD
  • Hu-antigen D
  • ELAV-like 4
  • Synonym symbol(s) HUD, PNEM
    DNA
    TYPE functioning gene
    STRUCTURE 155.77 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 4034 41.7 380 - 2015 25332105
    7 - 3911 - 383 - 2015 25332105
    7 - 3882 - 369 - 2015 25332105
    7 - 3804 - 366 - 2015 25332105
    7 - 3842 - 402 - 2015 25332105
    8 - 4066 - 365 - 2015 25332105
    7 - 4027 - 352 - 2015 25332105
    7 - 3992 - 366 - 2015 25332105
    4 - 2381 - 128 - 2015 25332105
    8 - 4136 - 365 - 2015 25332105
    7 - 4091 - 385 - 2015 25332105
    7 - 4062 - 371 - 2015 25332105
    6 - 4010 - 358 - 2015 25332105
    4 - 2451 - 133 - 2015 25332105
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas     Homo sapiens
    Nervousbrain     Homo sapiens
    Respiratorylung    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three copies of the RNP motif, binding to AU-rich elements (ARE), of early response-gene messenger
  • a HNS signal (HUR nuclear cytoplasmic shuttling sequence)
  • HOMOLOGY
    intraspecies homolog to HD
    Homologene
    FAMILY
  • HU protein family
  • CATEGORY RNA associated , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text shuttling the ERG class of mRNA from nuclear to the cytoplasm in response to regulatory signals
    basic FUNCTION
  • shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals, where they become stabilized, translated or rapidly degraded
  • regulating mRNA stability by binding preferentilally to adenine and uridine (AU) rich elements
  • implicated in the control of stabilization, nuclear export, and/or translation of specific mRNAs with AU-rich elements (AREs) in the 3'-untranslated region
  • involvement of ELAVL4 in microtubule-mediated regulation of mRNA expression within neuronal processes
  • is a pivotal regulator of insulin translation in pancreatic beta cells.
  • is likely necessary for the establishment of neocortical and hippocampal circuitry and is critical for their function
  • acting as a novel adaptor protein to recruit NXF1for efficient export of ARE-containing mRNAs in neuronal cells
  • neuronal RNA-binding protein implicated in neuronal development, plasticity, and diseases
  • is a transcriptional activator of ELAVL4 during neural stem/progenitor cells (NSCs) neuronal differentiation
  • functions as a novel repressor of lipid synthesis in pancreatic beta cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • can form a ternary complex together with both NXF1 and RNA
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with NXF1
  • is the first factors affecting the expression and activity of NOVA1 and, consequently, is major candidat for the physiological modulation of NOVA1-dependent processing of pre-mRNAs in neurons
  • EIF4A1 and poly(A)-binding activities of ELAVL4 are not only important for stimulating translation but also are essential for ELAVL4-induced neurite outgrowth
  • interacts with SMN1 and can rescue spinal muscular atrophy-like neuronal defects
  • stimulates cap-dependent translation through interactions with EIF4A1 and poly (A) tail
  • KHSRP is an important regulator of mRNA stability and axonal length that works in direct opposition to ELAVL4 to regulate the levels of GAP43 and other AU-rich element (ARE)-containing neuronal mRNAs
  • is an inducer of ATG5 expression and hence a critical regulator of autophagosome formation in pancreatic beta cells
  • direct effect of ELAVL4 on regulating translation of dendritic BDNF mRNAs to mediate local and activity-dependent increases in dendritic BDNF synthesis
  • promotes neuronal differentiation of neural stem/progenitor cells (NSCs) in the adult subventricular zone by stabilizing the mRNA of SATB1, a critical transcriptional regulator in neurodevelopment
  • cell & other
    REGULATION
    Other response to regulatory signals
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    modulating MYCN gene copy number in neuroblastoma
    Susceptibility
  • to to Parkinson disease with age-at-onset <40years
  • to paraneoplastic multifocal neurologic disorder
  • Variant & Polymorphism SNP SNP 5 associated with Parkinson risk in the early-onset in families (at least one affected with AAO <40 years)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • HuD KO mice are more susceptible to auditory-induced seizures, often resulting in death