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FLASH GENE
Symbol ELAVL3 contributors: - updated : 05-04-2006
HGNC name ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
HGNC id 3314
Location 19p13.2      Physical location : 11.562.142 - 11.591.803
Synonym name
  • ELAV-like protein 3
  • Hu antigen C
  • paraneoplastic cerebellar degeneration-associated antigen
  • paraneoplastic limbic encephalitis antigen 21
  • Synonym symbol(s) HUC, HUCL, MGC20653, PLE21
    DNA
    TYPE functioning gene
    STRUCTURE 26.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4682 - 367 - Behrends
    - - 4661 - 360 - Behrends
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Respiratorylung    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text at an early stage of neural development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three copies of the RNP motif, binding to AU-rich elements (ARE), of early response-gene messenger
  • a HNS signal (HUR nuclear cytoplasmic shuttling sequence)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text shuttling the ERG class of mRNA from nuclear to the cytoplasm in response to regulatory signals
    basic FUNCTION
  • shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals, where they become stabilized, translated or rapidly degraded, required for neuronal differentiation in the mammalian nervous system
  • implicated in the control of stabilization, nuclear export, and/or translation of specific mRNAs with AU-rich elements (AREs) in the 3'-untranslated region
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    Other response to regulatory signals
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS