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FLASH GENE
Symbol ELAVL3 contributors: - updated : 05-04-2006
HGNC name ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
HGNC id 3314
Location 19p13.2      Physical location : 11.562.142 - 11.591.803
Synonym name
  • ELAV-like protein 3
  • Hu antigen C
  • paraneoplastic cerebellar degeneration-associated antigen
  • paraneoplastic limbic encephalitis antigen 21
  • Synonym symbol(s) HUC, HUCL, MGC20653, PLE21
    DNA
    TYPE functioning gene
    STRUCTURE 26.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LDLR 19p13.2 low density lipoprotein receptor (familial hypercholesterolemia) FLJ90806 KIAA1518 LOC55908 19p13.2 hepatocellular carcinoma-associated gene TD26 TM4-B 19p13.2 tetraspanin TM4-B RAB3D 19p13.2 RAB3D, member RAS oncogene family LPPR2 19p13.2 lipid phosphate phosphatase-related protein type 2 UNQ501 19p13.2 MBC3205 LOC126075 19p13.2 hypothetical protein LOC126075 FLJ35119 19p13.2 hypothetical protein FLJ35119 EPOR 19p13.2 erythropoietin receptor RGL3 19p13.1-p13.2 erythropoietin receptor MGC20983 19p13.2 hypothetical protein MGC20983 PRKCSH 19p13.2 protein kinase C substrate 80K-H DKFZp547J036 19p13.2 hypothetical protein DKFZp547J036 ELAVL3 19p13.2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) LOC115950 19p13.2 hypothetical protein BC016816 SITPEC 19p13.2 likely ortholog of mouse signaling intermediate in Toll pathway-evolutionarily conserved CNN1 19p13.2 calponin 1, basic, smooth muscle MGC4549 19p13.2 hypothetical protein MGC4549 ACP5 19p13.3-p13.2 acid phosphatase 5, tartrate resistant LOC390889 19 similar to Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (38 kDa BFA-dependent ADP-ribosylation substrate) (BARS-38) LOC199692 19p13.2 similar to Zinc finger protein 136 LOC342970 19p13.2 similar to Zinc finger protein 20 (Zinc finger protein KOX13) (DKFZp572P0920) LOC284387 19p13.2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC390890 19 hypothetical gene supported by AK126753 ZNF441 19p13.13 zinc finger protein 441 ZNF491 19p13.2 zinc finger protein 491 ZNF440 19p13.13 zinc finger protein 440 ZNF439 19p13.13 zinc finger protein 439
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4682 - 367 - Behrends
    - - 4661 - 360 - Behrends
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Respiratorylung    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text at an early stage of neural development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three copies of the RNP motif, binding to AU-rich elements (ARE), of early response-gene messenger
  • a HNS signal (HUR nuclear cytoplasmic shuttling sequence)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text shuttling the ERG class of mRNA from nuclear to the cytoplasm in response to regulatory signals
    basic FUNCTION
  • shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals, where they become stabilized, translated or rapidly degraded, required for neuronal differentiation in the mammalian nervous system
  • implicated in the control of stabilization, nuclear export, and/or translation of specific mRNAs with AU-rich elements (AREs) in the 3'-untranslated region
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    Other response to regulatory signals
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS