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FLASH GENE
Symbol ELAVL2 contributors: - updated : 05-04-2006
HGNC name ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
HGNC id 3313
Location 9p21      Physical location : 23.690.104 - 23.826.063
Synonym name nervous system specific RNA-binding protein
Synonym symbol(s) HELN1, HUB, ELAV
DNA
TYPE functioning gene
STRUCTURE 134.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx    
Nervousbrain    
Reproductivefemale systemovary   
 male systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three copies of the RNP motif, binding to AU-rich elements (ARE), of early response-gene messenger
  • a HNS signal (HUR nuclear cytoplasmic shuttling sequence)
    • HOMOLOGY
    intraspecies homolog to HEL-N1
    Homologene
    FAMILY ELAV rnp proteins family
    CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals, where they become stabilized, translated or rapidly degraded, required for normal neuronal development in the embryonic CNS
  • implicated in the control of stabilization, nuclear export, and/or translation of specific mRNAs with AU-rich elements (AREs) in the 3'-untranslated region
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA RNA binding protein
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS