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FLASH GENE
Symbol ELAVL2 contributors: - updated : 05-04-2006
HGNC name ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
HGNC id 3313
Location 9p21      Physical location : 23.690.104 - 23.826.063
Synonym name nervous system specific RNA-binding protein
Synonym symbol(s) HELN1, HUB, ELAV
DNA
TYPE functioning gene
STRUCTURE 134.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
KIAA1354 9p22 KIAA1354 protein IFNA6 9p22 interferon, alpha 6 IFNA13 9p22 interferon, alpha 13 IFNA2 9p22 interferon, alpha 2 IFNA8 9p22 interferon, alpha 8 LOC392293 9 similar to Interferon omega-1 precursor (Interferon alpha-II-1) IFNA1 9p22 interferon, alpha 1 LOC392294 9 similar to interferon-alpha IFNT1 9p21.3 interferon tau-1 LOC347217 9p21.3 similar to KH-type splicing regulatory protein (FUSE binding protein 2); KH-type splicing regulatory protein (FUSE-binding protein 2) MTAP 9p22-p21 methylthioadenosine phosphorylase LOC51198 9p21-p22 susceptibility protein NSG-x CDKN2A 9p21.3 cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) CDKN2B 9p21.3 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) LOC392295 9 similar to ubiquitin A-52 residue ribosomal protein fusion product 1 DMRTA1 9p21.2 DMRT-like family A1 LOC392296 9 similar to Chloride intracellular channel protein 4 (Intracellular chloride ion channel protein p64H1) LOC138267 9p21.2 similar to hypothetical protein ELAVL2 9p21 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) LOC389707 9 LOC389707 LOC389708 9 hypothetical gene supported by BC017510; BC046919
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx    
Nervousbrain    
Reproductivefemale systemovary   
 male systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three copies of the RNP motif, binding to AU-rich elements (ARE), of early response-gene messenger
  • a HNS signal (HUR nuclear cytoplasmic shuttling sequence)
  • HOMOLOGY
    intraspecies homolog to HEL-N1
    Homologene
    FAMILY ELAV rnp proteins family
    CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals, where they become stabilized, translated or rapidly degraded, required for normal neuronal development in the embryonic CNS
  • implicated in the control of stabilization, nuclear export, and/or translation of specific mRNAs with AU-rich elements (AREs) in the 3'-untranslated region
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA RNA binding protein
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS