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FLASH GENE
Symbol ELAVL1 contributors: mct/npt/pgu - updated : 16-09-2016
HGNC name ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
HGNC id 3312
Location 19p13.2      Physical location : 8.023.457 - 8.070.529
Synonym name
  • Hu antigen R
  • embryonic lethal, abnormal vision, drosophila, homolog-like 1
  • Synonym symbol(s) HUR, HUA, ELAV1, MelG
    DNA
    TYPE functioning gene
    STRUCTURE 47.07 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 6075 - 326 - 2009 19647848
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Endocrineparathyroid   highly
    Reproductivemale systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three copies of the RNP motif, binding to AU-rich elements (ARE), of early response-gene messenger
  • a HNS signal (HUR nuclear cytoplasmic shuttling sequence)
  • an RNA-binding region containing two N-terminal RNA-recognition motif domains bound to an 11-base RNA fragment
  • HOMOLOGY
    Homologene
    FAMILY
  • RRM ELAV (embryonic lethal abnormal vision) family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • localizes first to the nucleus and then to the cytoplasm during muscle differentiation
  • predominantly nuclear RNA-binding protein, but translocates to the cytoplasm in response to stress and proliferative signals, where it stabilizes or modulates the translation of target mRNAs
  • during apoptosis, however, ELAVL1 accumulates in the cytoplasm
  • interacts with TNPO2 and thus blocks the re-import of ELAVL1 into the nucleus
  • is tyrosine-phosphorylated by JAK3, leading to modification of subcytoplasmic localization
  • basic FUNCTION
  • shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals, where they become stabilized, translated or rapidly degraded
  • key mediator of posttranscriptional regulation and expression of the SLC11A1 gene
  • involved in the regulation of protein synthesis
  • functions as a repressor of HIV-1 IRES activity and acts as an activator of the HCV IRES
  • has a role in the post-transcriptional regulation of HCV and HIV-1 gene expression
  • important regulator of gene expression, controlling the localization, stabilization, and translation of many different mRNAs
  • seems to play a positive role in both regulation of BCL2 mRNA translation and mRNA stability
  • RNA-binding protein regulating the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins
  • is an essential regulator of mesenchymal responses during lung branching
  • stabilizer of mRNA, having important roles in regulating the localization, translation, and stability of its targets, thus having a substantial ability to impact gene expression
  • involvement during spermatogenesis
  • implicated in a variety of biological processes as well as being linked with a number of diseases, including cancer (pMID: 21890634)
  • facilitates RBM38-mediated growth suppression by repressing MYC expression
  • CELF1 and ELAVL1 jointly regulate the translation of occludin and play a crucial role in the maintenance of tight junction (TJ) integrity in the intestinal epithelial cell monolayer
  • is a post-transcriptional factor, which acts mainly as a positive regulator of gene expression by binding to specific mRNAs whose corresponding proteins are fundamental for key cellular functions
  • SQSTM1 is decreased through autophagy-mediated degradation, while ELAVL1 through the proteasomal pathway
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • component of BCL2 messenger ribonucleoprotein (mRNP) complexes
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with HADHB, REN, PCBP1
  • interaction with ATF2 (ELAVL1 silencing rendered the ATF2 mRNA unstable and prevented increases in ATF2 mRNA and protein)
  • interacting with TNPO2 (ELAVL1 is localized to the nucleus of myoblasts by active TNPO2-mediated import)
  • interacting with PTGS2 (can stabilize the mRNA of PTGS2, and cytoplasmic expression of ELAVL1 is associated with increased PTGS2 expression in some cancers)
  • polyamines modulate the stability of JUND mRNA in intestinal epithelial cells through ELAVL1 and HNRNPD
  • ZNF385A regulates TP53 expression in cooperation with ELAVL1
  • ELAVL1 bind and control the FGF10 and TBX4 mRNAs
  • interacting with TNPO2 (normally responsible for the nuclear import of the RNA-binding protein ELAVL1)
  • HSPA2 is a target for ELAVL1
  • HNRNPD and ELAVL1 bind to VEGF ARE RNA under both normoxic and hypoxic conditions
  • ELAVL1 is a target of RBM38 and a mediator of RBM38-induced growth suppression
  • promotes OCLN translation by blocking occludin mRNA translocation to P-bodies via the displacement of ELAVL1
  • RNA-dependent interactions of RALY with MATR3, PABPC1 and ELAVL1
  • CARM1 represses replicative senescence by methylating ELAVL1 and thereby enhancing ELAVL1 ability to regulate the turnover of CCNA1, CCNB1, FOS, SIRT1, and CDKN2A mRNAs (
  • CARM1 catalyzes the methylation of ELAVL1
  • ELAVL1 is a novel posttranscriptional regulator of ABCA1 expression and cellular cholesterol homeostasis
  • complex role for HSF1 in the regulation of ELAVL1 and CTNNB1 expression that may be significant in mammary carcinogenesis
  • ELAVL1 and PARN destabilize Cat2 transcribed nuclear RNA (Ctn RNA) in absence of ADARB1, indicating that ADARB1 stabilizes Ctn RNA by antagonizing its degradation by PARN and ELAVL1
  • ELAVL1 stabilizes ATP6V0D2 mRNA, which is required for the TLR3-mediated innate immune responses
  • critical role of ELAVL1 in regulating lipid transport and ATP synthesis, by regulating the splicing of APOB mRNA and the translation of UQCRB and NDUFB6
  • cell & other
    REGULATION
    inhibited by RNASEL (overexpression of RNASEL decreases cellular growth and downmodulates the RNA-binding protein, ELAVL1, a regulator of cell-cycle progression and tumorigenesis)
    Other phosphorylated by CDK1 during G2, thereby helping to retain it in the nucleus in association with 14-3-3 and hindering its post-transcriptional function and anti-apoptotic influence
    regulated by polyamines (regulate the subcellular localization of the RNA-binding protein ELAVL1, which stabilizes its target transcripts such as nucleophosmin and TP53 mRNAs)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS