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FLASH GENE
Symbol EIF5B contributors: mct - updated : 29-04-2015
HGNC name eukaryotic translation initiation factor 5B
HGNC id 30793
Location 2q11.2      Physical location : 99.953.833 - 100.016.726
Synonym name
  • translation initiation factor IF2
  • KIAA0741 gene product
  • Synonym symbol(s) LOC51590, KIAA0741, IF2
    DNA
    TYPE functioning gene
    STRUCTURE 62.91 kb     24 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 4698 - 1220 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminus promotes 70S initiation complex (IC) formation by stabilizing the productive sampling of the 50S subunit during 30S IC joining
  • central GTP-binding domain
  • C terminus highly conserved compared with its homolog
  • HOMOLOGY
    interspecies homolog to murine Eif5b
    intraspecies homolog to yeast bacterial and yeast IF2 (initiation factor 2)
    Homologene
    FAMILY IF2 family
    CATEGORY RNA associated , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in general translation initiation by promoting the binding of the formylmethionine tRNA to ribosomes and by GTP hydrolysis (essential for translation initiation)
  • ribosome-dependent GTPase that mediates displacement of initiation factors from the 40S ribosomal subunit in 48S initiation complexes and joining of 40S and 60S subunits
  • promotes GTP-dependent ribosomal subunit joining in the final step of the translation initiation pathway
  • GTPase that positions the initiator tRNA on the 30S ribosomal initiation complex and stimulates its assembly to the 50S ribosomal subunit to make the 70S ribosome (PMID
  • eukaryal translational GTPase that catalyzes ribosomal subunit joining to form elongation-competent ribosomes
  • employs a novel domain release mechanism to catalyze ribosomal subunit joining
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DDX4 interacts with the general translation initiation factor eIF5B, and thus may regulate translation of specific mRNAs (this interaction with the general translation factor EIF5B is essential for DDX4 function during development)
  • interactions between EIF1AX and EIF5B are being continuously rearranged during translation initiation
  • EIF5 interacts with EIF5B and may help recruit EIF5B to the PIC (an EIF5B-binding motif was identified at the C-terminus of eIF5, similar to that found in EIF1AX)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS