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FLASH GENE
Symbol EIF4G2 contributors: mct/pgu - updated : 19-02-2019
HGNC name eukaryotic translation initiation factor 4 gamma, 2
HGNC id 3297
Location 11p15.4      Physical location : 10.818.593 - 10.830.582
Synonym name
  • death-associated protein 5
  • aging-associated protein 1
  • eIF-4-gamma 2
  • eukaryotic translation initiation factor 4G-like 1
  • Novel APOBEC1 target 1
  • Synonym symbol(s) DAP5, P97, NAT1, FLJ41344, AAG1
    DNA
    TYPE functioning gene
    STRUCTURE 11.99 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    text structure non-AUG translation initiation site evolutionarily conserved
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 3911 102 907 - 2005 16410684
    21 - 3797 98 869 - 2005 16410684
  • in apoptosis, cleaved by caspases at position 792, yielding an 86-kDa C-terminal truncated isoform that promotes translation of several mRNAs mediated by an internal ribosome entry site
  • - - - 86 - - 2008 18722383
    during apoptosis, I2 is cleaved by caspases at position 792, yielding an 86-kDa C-terminal truncated isoform that promotes translation of several mRNAs mediated by an internal ribosome entry site
    22 - 4028 - 907 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     mouthtongue  highly
    Hearing/Equilibriumear   highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • EIF4G2 N-terminus plays an alternative role in initiation factor assembly
  • a large middle, alpha helical domain RNA binding
  • two potential PKC phosphorylation sites
  • two caseine kinase II sites
  • C-terminal region extending between amino acids 730 and 897 with four HEAT-Repeats homologous to the C-terminal domain of eIF4GI, eIF5, and eIF2Bepsilon , maybe involved in interactions with eIF2
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to mammalian eIF-4G (EIF4G)
    intraspecies homolog to EIF4G
    homolog to homologous to the C-terminal two thirds of eukaryotic translation initiation factor 4G (EIF4g1
    Homologene
    FAMILY
  • eukaryotic translation initiation factor (EIF4G) family
  • CATEGORY chaperone/stress , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • binding of mRNA cap structure to ribosome 43S
  • increasing the poly (A)-binding protein (PABPx) RNA binding activity
  • controlling expression of genes in the retinoic pathway of cellular differentiation
  • polysome associated in proliferating cells and moves to stress granules in stressed, nonapoptotic cells that can activate translation independent of caspase cleavage
  • functions as a scaffold protein promoting cap-independent translation of proteins
  • crucial for continuous cell survival in nonstressed cells
  • having a necessary role for maintaining cell survival during mitosis by promoting cap-independent translation of at least two prosurvival proteins BCL2 and CDK1
  • EIF4G1 clearly has specific functions that do not overlap that of EIF4G2
  • EIF4G2-mediated translation of a specific set of proteins is critical for the transition from pluripotency to differentiation, highlighting the importance of cap-independent translation in stem cell fate decisions
  • is involved in the translation of proteins that are required for cell differentiation
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • scaffold protein for the assembly of eIF4A, eIF4B, eIF4E, MNK1, EIF4EBPs, PABPC1 to form the eukaryotic translation initiation complex eIF4F
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the poly (A)-binding protein (PABPx)
  • target of APOBEC1, EIF4A, EIF3A
  • through its ability to regulate IRES-dependent translation of the TP53 mRNA, EIF4G2 may control the ratio between different TP53 isoforms encoded by a single mRNA.
  • EIF4G2 associates with EIF2B4 and EIF4A1 to stimulate Internal Ribosome Entry Sites (IRES)-dependent translation of cellular mRNAs
  • EIF4G2 and EIF4G1 share many binding proteins, such as the eukaryotic translation initiation factors EIF3A and EIF4A1 and ribosomal proteins
  • YTHDF3 cooperates with two cofactors, PABPC1 and EIF4G2, to promote FOXO3 translation by binding to the translation initiation region of FOXO3 mRNA
  • cell & other
    REGULATION
    Other in apoptosis cleaved by caspases at position 792, yielding an 86-kDa C-terminal truncated isoform that promotes translation of several mRNAs mediated by an internal ribosome entry site
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in transitional cell carcinomas of the bladder
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Nat1-null mouse embryonic stem cells (mES cells) are resistant to differentiation