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FLASH GENE
Symbol EIF4G2 contributors: mct/pgu - updated : 11-07-2009
HGNC name eukaryotic translation initiation factor 4 gamma, 2
HGNC id 3297
Location 11p15.3      Physical location : 10.818.593 - 10.830.582
Synonym name
  • death-associated protein 5
  • aging-associated protein 1
  • eIF-4-gamma 2
  • eukaryotic translation initiation factor 4G-like 1
  • Synonym symbol(s) DAP5, P97, NAT1, FLJ41344, AAG1
    DNA
    TYPE functioning gene
    STRUCTURE 11.99 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    text structure non-AUG translation initiation site evolutionarily conserved
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA0033 11p15.3 KIAA0033 protein IPO7 11p15.3 importin 7 ZNF143 11p15.4-p15.3 zinc finger protein 143 (clone pHZ-1) WEE1 11p15.3 WEE1 homolog (S. pombe) LOC387752 11 similar to 60S ribosomal protein L23a LOC387753 11 similar to 60S ribosomal protein L21 SWAP70 11p15 Homo sapiens SWAP-70 protein (SWAP70), mRNA. CMT4B2 11p15.3 Charcot-Marie-Tooth neuropathy 4B2 (autosomal recessive, with myelin outfolding) ADM 11p15.4 adrenomedullin LOC338749 11p15.3 hypothetical LOC338749 AMPD3 11p15 adenosine monophosphate deaminase (isoform E) RNF141 11p15.3 ring finger protein 141 XLKD1 11p15 extracellular link domain containing 1 MRVI1 11p15 murine retrovirus integration site 1 homolog SH2BP1 11pter-p15.4 SH2 domain binding protein 1 (tetratricopeptide repeat containing) EIF4G2 11p15 eukaryotic translation initiation factor 4 gamma, 2 LOC58486 11p15.3 transposon-derived Buster1 transposase-like protein MGC71806 11p15.3 similar to Hypothetical protein LOC233733 USP47 11p15.2 ubiquitin specific protease 47 RIG 11p15.1 ubiquitin specific protease 47 DKK3 11p15.2 dickkopf homolog 3 (Xenopus laevis) MICAL2 11p15.2 dickkopf homolog 3 (Xenopus laevis)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 3911 102 907 - 2005 16410684
    21 - 3797 98 869 - 2005 16410684
  • in apoptosis, cleaved by caspases at position 792, yielding an 86-kDa C-terminal truncated isoform that promotes translation of several mRNAs mediated by an internal ribosome entry site
  • - - - 86 - - 2008 18722383
    during apoptosis, I2 is cleaved by caspases at position 792, yielding an 86-kDa C-terminal truncated isoform that promotes translation of several mRNAs mediated by an internal ribosome entry site
    22 - 4028 - 907 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     mouthtongue  highly
    Hearing/Equilibriumear   highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a large middle, alpha helical domain RNA binding
  • two potential PKC phosphorylation sites
  • two caseine kinase II sites
  • C-terminal region extending between amino acids 730 and 897 with four HEAT-Repeats homologous to the C-terminal domain of eIF4GI, eIF5, and eIF2Bepsilon , maybe involved in interactions with eIF2
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to mammalian eIF-4G (EIF4G)
    intraspecies homolog to EIF4G
    Homologene
    FAMILY
  • eukaryotic translation initiation factor (EIF4G) family
  • CATEGORY chaperone/stress , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • binding of mRNA cap structure to ribosome 43S
  • increasing the poly (A)-binding protein (PABPx) RNA binding activity
  • controlling expression of genes in the retinoic pathway of cellular differentiation
  • polysome associated in proliferating cells and moves to stress granules in stressed, nonapoptotic cells that can activate translation independent of caspase cleavage
  • functions as a scaffold protein promoting cap-independent translation of proteins
  • crucial for continuous cell survival in nonstressed cells
  • having a necessary role for maintaining cell survival during mitosis by promoting cap-independent translation of at least two prosurvival proteins BCL2 and CDK1
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • scaffold protein for the assembly of eIF4A, eIF4B, eIF4E, MNK1, EIF4EBPs, PABPC1 to form the eukaryotic translation initiation complex eIF4F
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the poly (A)-binding protein (PABPx)
  • target of APOBEC1, EIF4A, EIF3
  • cell & other
    REGULATION
    Other in apoptosis cleaved by caspases at position 792, yielding an 86-kDa C-terminal truncated isoform that promotes translation of several mRNAs mediated by an internal ribosome entry site
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in transitional cell carcinomas of the bladder
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS