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FLASH GENE
Symbol EIF4ENIF1 contributors: mct - updated : 24-10-2016
HGNC name eukaryotic translation initiation factor 4E nuclear import factor 1
HGNC id 16687
Location 22q12.2      Physical location : 31.835.345 - 31.885.874
Synonym name
  • eIF4E transporter
  • Synonym symbol(s) 4E-T, Clast4
    DNA
    TYPE functioning gene
    STRUCTURE 52.99 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    SLC35E4 22q12.2 solute carrier family 35, member E4 LOC391328 22 similar to tum- transplantation antigen P198 DUSP18 22q12.1 dual specificity phosphatase 18 OSBP2 22q12.2 oxysterol binding protein 2 FLJ35801 22q12.2 hypothetical protein FLJ35801 ZCWCC1 22q12.2 zinc finger, CW-type with coiled-coil domain 1 FLJ20618 22q12.2 hypothetical protein FLJ20618 LOC388893 22 LOC388893 SMTN 22q12.2 smoothelin SELM 22q12.2 selenoprotein SelM PIB5PA 22q12.2 phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A PLA2G3 22q11.2-q13.2 phospholipase A2, group III FLJ38628 22q12.3 hypothetical protein FLJ38628 AGTRL2 22q12.2 angiotensin II receptor-like 2 LIMK2 22q12.2 LIM domain kinase 2 PPP1R14BP1 22q12 protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene 1 MGC17330 22q12.2 HGFL gene ZNF278 22q12.2 zinc finger protein 278 MGC15705 22q12.3 hypothetical protein MGC15705 FLJ20464 22q12.3 hypothetical protein FLJ20464 DRG1 22q12.2 developmentally regulated GTP binding protein 1 EIF4ENIF1 22q11.2 eukaryotic translation initiation factor 4E nuclear import factor 1 KIAA0542 22q12.2 KIAA0542 gene product PISD 22q12.2 phosphatidylserine decarboxylase LOC388894 22 similar to Phosphatidylserine decarboxylase proenzyme MGC50372 22q12.3 hypothetical protein MGC50372 FLJ23059 22q12.3 hypothetical protein FLJ23059 KIAA0645 22q12.2-q12.3 hypothetical protein FLJ23059 HSN44A4A 22q12.1-q12.3 hypothetical protein HSN44A4A YWHAH 22q12.2 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide LOC391329 22 similar to ribosomal protein S17 SLC5A1 22q12.3 solute carrier family 5 (sodium/glucose cotransporter), member 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 3704 - 985 - 2013 23991149
    17 - 3182 - 811 - 2013 23991149
    19 - 3680 - 985 - 2013 23991149
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
     mouth   moderately
     pharynx   moderately
    Endocrineadrenal gland   highly
    Nervousnerve   highly
    Reproductivefemale systembreastmammary gland moderately
     female systemuterus  moderately
     male systemtestis  highly
    Respiratoryrespiratory tracttrachea  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single N-terminal EIF4E-binding site
  • a bipartite nuclear localization signal (NLS)
  • two leucine-rich nuclear export signals
  • a conserved CUP-homology domain (CHD) interacts directly with DDX6 in both the presence and absence of the central MIF4G domain of CNOT1
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Eif4enif1 (90.2 pc)
    Homologene
    FAMILY
  • eukaryotic translation initiation factor
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    text
  • predominantly cytoplasmic
  • basic FUNCTION
  • mediating the nuclear import of EIF4E by a piggy-back mechanism
  • shuttling between the nucleus and the cytoplasm in a CRM1-dependent manner
  • P bodies (PB) assembly is regulated by a two-step mechanism involving a EIF4ENIF1-dependent assembly stage in unstressed cells and a EIF4ENIF1 phosphorylation-dependent aggregation stage in response to stress stimuli
  • acting as a translation initiation factor
  • conserved yet unconventional mechanism of EIF4ENIF1 silencing of particular subsets of mRNAs
  • promotes mRNA turnover by physically linking the 3prime-terminal mRNA decay machinery to the 5prime cap via its interaction with EIF4E
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex with importin A and B mediating the nuclear import of EIF4E
  • EIF4E/EIF4ENIF1 complex is present in granules with the processing body proteins LSM1 and DDX6, and disruption of this complex causes premature and enhanced neurogenesis and neural precursor depletion
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with EIF4E
  • interacting with importin beta via a direct interaction with importin alpha
  • binding to mRNA 5'cap-binding protein
  • must interact with EIF4E to engender mRNA decay
  • DDX6 interacts with the CNOT1 complex and functions in concert with several post-transcriptional regulators, including EDC3, and EIF4ENIF1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    associated with primary ovarian insufficiency
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS