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FLASH GENE
Symbol EIF4EBP3 contributors: - updated : 12-10-2007
HGNC name eukaryotic translation initiation factor 4E binding protein 3
HGNC id 3290
Location 5q31.3      Physical location : 139.927.250 - 139.929.163
Synonym symbol(s) 4E-BP3
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
PFDN1 5q31-q32 prefoldin 1 DTR 5q23-q31 diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) SLC4A9 5q31 solute carrier family 4, sodium bicarbonate cotransporter, member 9 FLJ20288 SLC35A4 5q31.3 solute carrier family 35, member A4 EIF4EBP3 5q31.3 eukaryotic translation initiation factor 4E binding protein 3 SRA1 5q31.3 steroid receptor RNA activator 1 APBB3 5q31 amyloid beta (A4) precursor protein-binding, family B, member 3 CD14 5q31.1 CD14 antigen PRO1580 5q31.3 hypothetical protein PRO1580 NDUFA2 5q31.2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa IK 2p15-p14 IK cytokine, down-regulator of HLA II FLJ20195 5q31.3 hypothetical protein FLJ20195 DND1 5q31.3 dead end homolog 1 (zebrafish) HARS 5q31.1 histidyl-tRNA synthetase HARSL 5q31.1-q33.2 histidyl-tRNA synthetase-like FLJ31121 5q31.3 hypothetical protein FLJ31121 PCDHA1 5q31.3 protocadherin alpha 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 698 10 100 - Poulin
- - 8319 277 2617 - Poulin
  • Co-transcription with ANKHD1 (the neighboring upstream gene) generates a transcript (MASK-BP3) encoding a fusion protein comprised of the majority of the MASK protein sequence and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments
  • infrequent but naturally occurring co-transcript product
  • unknown function
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   highly
    Respiratoryrespiratory tractlarynx  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • middle region containing the EIF4E binding motif
  • phosphorylation sites
  • secondary structure an alpha helical structure involved in the control translation initiation
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Eif4ebp3
    intraspecies paralog to EIF4EBP1
    paralog to EIF4EBP2
    Homologene
    FAMILY EIF4EBP family
    CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus
    basic FUNCTION
  • translational repressor,negatively regulating translation by eIF4E (overexpression specifically reduces EIF4E-dependent translation)
  • acting as a tumor suppressor
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • assembling with eIF4A, eIF4B, eIF4E, eIF4EBP1, eIF4EBP2, MNK1, eIF4G and PABPC1 to form the eukaryotic translation initiation complex eIF4F
  • INTERACTION
    DNA
    RNA
    small molecule
    protein binding to EIF4E into the nucleus
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with ANKHD1 in leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target for cancer therapy, potentially (small-molecule inhibitors that pharmacologically mimic function)
    ANIMAL & CELL MODELS