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FLASH GENE
Symbol EIF4A1 contributors: mct/npt - updated : 24-06-2016
HGNC name eukaryotic translation initiation factor 4A, isoform 1
HGNC id 3282
Location 17p13.1      Physical location : 7.476.056 - 7.482.324
Synonym name
  • eukaryotic,cap structure,translocation factor EIF4A,isoform 1
  • ATP-dependent RNA helicase eIF4A-1
  • eukaryotic initiation factor 4AI
  • Synonym symbol(s) DDX2A, EIF-4A
    EC.number 3.6.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 6.27 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    KCTD11 17p13.2 potassium channel tetramerisation domain containing 11 LOC339168 17p13.2 hypothetical protein LOC339168 TNK1 17p13.1 tyrosine kinase, non-receptor, 1 PLSCR3 17p13.2 phospholipid scramblase 3 MGC40107 17p13.2 hypothetical protein MGC40107 NLGN2 17p13 neuroligin 2 LOC374768 17p13.2 hypothetical protein LOC374768 LOC201243 17p13.2 hypothetical protein LOC201243 LOC388329 17 similar to ENSANGP00000015193 FLJ36878 17p13.2 hypothetical protein FLJ36878 LOC388330 17 LOC388330 FGF11 17p13.1 fibroblast growth factor 11 CHRNB1 17p13.1 cholinergic receptor, nicotinic, beta polypeptide 1 (muscle) ZBTB4 17p13.2 zinc finger and BTB domain containing 4 POLR2A 17p13.1 polymerase (RNA) II (DNA directed) polypeptide A, 220kDa TNFSF12 17p13.1 tumor necrosis factor (ligand) superfamily, member 12 TNFSF13 17p13.1 tumor necrosis factor (ligand) superfamily, member 13 SENP3 17p13 tumor necrosis factor (ligand) superfamily, member 13 EIF4A1 17p13.1 eukaryotic translation initiation factor 4A, isoform 1 CD68 17p13.1 CD68 antigen MPDU1 17p13.1-p12 mannose-P-dolichol utilization defect 1 SOX15 17p12.3 SRY (sex determining region Y)-box 15 FXR2 17p13.1 fragile X mental retardation, autosomal homolog 2 SAT2 17p13.2 spermidine/spermine N1-acetyltransferase 2 SHBG 17p13.1 sex hormone-binding globulin
    regionally located tightly linked to CD8 in same orientation
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1844 46 406 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a DEAD/H box (Asp-Glu-Ala-Asp/His
  • a C terminal RNA helicase domain
  • HOMOLOGY
    interspecies ortholog to murine Eif401
    homolog to hepatitis C virus non structural protein 3 helicase
    Homologene
    FAMILY
  • eukaryotic translation initiation factor
  • DEAD box protein family
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • ATP-dependent RNA helicase
  • involved in the binding of capped mRNA to 40S subunit of ribosome and in mtDNA metabolism
  • plays a key role in unwinding of mRNA and scanning during translation initiation (Marintchev 2008)
  • CELLULAR PROCESS nucleotide, transcription
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • assembling with eIF4E and eIF4E kinase (MNK1), eIF4B, eIF4G, PABPC1 to form eIF4F eukaryotic translation initiation complex
  • part of eIF4A/4G/4H helicase complex (Marintchev 2008)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ATP
  • protein
  • interacting with PAIP1
  • interacting with UPF2
  • interacting with two accessory factors, eIF4B and eIF4H(forms a stable complex with RNA in the with RNA in the presence of AMPPNP and that eIF4B or eIF4H can add to this complex, also dependent on AMPPNP) (Rozovsky 2008)
  • PAIP1 act as a translational activator in 5 prime cap-dependent translation by interacting with PABPC1 and the initiation factors EIF4A1 and EIF3A
  • EIF4A1 and poly(A)-binding activities of ELAVL4 are not only important for stimulating translation but also are essential for ELAVL4-induced neurite outgrowth
  • direct association of PKP1 with the eukaryotic translation initiation factor 4A1 (EIF4A1), and PKP1 directly promoted EIF4A1 adenosine triphosphatase activity
  • EIF4G2 associates with EIF2B4 and EIF4A1 to stimulate Internal Ribosome Entry Sites (IRES)-dependent translation of cellular mRNAs
  • EIF4G2 and EIF4G1 share many binding proteins, such as the eukaryotic translation initiation factors EIF3 and EIF4A1 and ribosomal proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS