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FLASH GENE
Symbol EIF3H contributors: mct - updated : 05-03-2011
HGNC name eukaryotic translation initiation factor 3, subunit H
HGNC id 3273
Location 8q24.11      Physical location : 117.657.055 - 117.768.062
Synonym name
  • transforming growth factor beta receptor interacting protein 1
  • eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa
  • Synonym symbol(s) EIF3P40, EIF3GAMMA, EIF3S3
    DNA
    TYPE functioning gene
    STRUCTURE 111.00 kb     8 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map cen - D8S1457 - D8S1668 - EIF3H - D8S269 - D8S1802 - D8S1726 - D8S1979 - D8S1484 - D8S1968 - qter
    Authors Nupponen (00)
    Text see RAD21
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1286 - 352 - 2000 10825005
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Lymphoid/Immunelymph node    
     spleen   highly
    Reproductivefemale systemuteruscervix highly
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    one JAB/MPN domain
    HOMOLOGY
    interspecies homolog to murine Eif3s3
    Homologene
    FAMILY eukaryotic translation initiation factor family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • eukaryotic translation initiation factor
  • stabilizing initiator Met tRNA (TRIMs) binding to 40S subunits
  • regulates cell growth and viability, and overexpression of the gene may provide growth advantage to the cancer cells
  • promoting the association of Met-tRNA and mRNA
  • high EIF3H levels directly stimulate protein synthesis, resulting in the establishment and maintenance of the malignant state in cells
  • plays a central role in translation initiation
  • has specific as well as redundant functions during early development
  • CELLULAR PROCESS nucleotide, transcription, initiation
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the EIF3 multiprotein complex, 600kDa
    INTERACTION
    DNA
    RNA binding to the 40S ribosome
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    breast and prostate cancer, hepatocellular carcinoma
    tumoral   amplification    
    with MYC, are frequently coamplified in non-small cell lung cancer and a high copy number correlates with increased epidermal growth factor receptor tyrosine kinase inhibitors sensitivity
    Susceptibility to colorectal cancer(CRC)
    Variant & Polymorphism SNP , other
  • increasing the risk of colorectal cancer
  • rs16888589 increases the expression of EIF3H and increased expression of this gene increases CRC growth
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS