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FLASH GENE
Symbol EIF3G contributors: mct - updated : 11-02-2012
HGNC name eukaryotic translation initiation factor 3, subunit G
HGNC id 3274
Location 19p13.2      Physical location : 10.225.690 - 10.230.599
Synonym name
  • eukaryotic translation initiation factor 3 subunit p42
  • eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa
  • Synonym symbol(s) EIF3-P42, EIF3-P44, EIF3S4, eIF3-delta
    DNA
    TYPE functioning gene
    STRUCTURE 4.91 kb     11 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1127 - 320 - 1999 9973622
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   predominantly
    Nervousnervecranial nerve  moderately
    Reproductivefemale systemuteruscervix highly
     female systemovary  moderately
    Respiratorylung   moderately
    Skin/Tegumentskin   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumskeletal highly
    cell lineage
    cell lines Hela cells
    fluid/secretion
    at STAGE
    physiological period embryo, fetal, pregnancy
    Text embryonic tissue
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RNA binding motif near its C terminus
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Tip35p
    homolog to rattus Eif3s4 (98.44 pc)
    homolog to murine Eif3g (98.44 pc)
    Homologene
    FAMILY eukaryotic translation initiation factor family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus
    basic FUNCTION
  • stabilizing initiator Met tRNA (TRIMs) binding to 40S subunits
  • promoting the association of MET tRNA and mRNA
  • translation initiation factor EIF3 acts as the key orchestrator of the canonical initiation pathway in eukaryotes
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • components of the EIF3 multiprotein complex, 600kDa
  • INTERACTION
    DNA
    RNA
  • binding to 40S ribosomal subunits
  • binding to the 18S RNA (required for mRNA binding)
  • binding beta-globin mRNA
  • small molecule
    protein
  • interacting EIF3A & EIF3S12
  • PELO interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton
  • CTIF, which has been shown to be preferentially involved in NCBP1-dependent translation but not EIF4E-dependent translation, specifically interacts with EIF3G, a component of the EIF3 complex involved in ribosome recruitment
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS