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FLASH GENE
Symbol EIF3F contributors: mct - updated : 13-11-2013
HGNC name eukaryotic translation initiation factor 3, subunit F
HGNC id 3275
Location 11p15.4      Physical location : 8.008.866 - 8.017.716
Synonym name
  • eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa
  • eIF3 p47 subunit
    • Synonym symbol(s) EIF3S5, eIF3-p47
    EC.number 3.4.19.12
    DNA
    TYPE functioning gene
    STRUCTURE 8.85 kb     8 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map cen - D17S791 - D17S931 - MYL4 - ITGB3 - GIP - D17S1795 - D17S809 - D17S788 - D17S1865 - D17S790 - HLF HLF - EIF3F - MPO - D17S1604 - D17S923 - D17S924 - D17S794 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1274 37.4 357 - 2008 18354498
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Hearing/Equilibriumearinnercochlea highly
    Lymphoid/Immunelymph node   highly
     tonsils   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatum  highly
    cell lineage
    cell lines Hela cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal rich protein region
  • a MPN (JAB/Mov34) domain
  • a conserved TOS motif that during terminal muscle differentiation connects MTOR/raptor complex
  • highly conserved C-terminal domain is implicated for FBXO32-directed polyubiquitination and proteasomal degradation
    • mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to murine Eif3f (93.5 pc)
    homolog to rattus Eif3s5 (93.2 pc)
    Homologene
    FAMILY
  • eukaryotic translation initiation factor family
  • peptidase M67 family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • stabilizing initiator Met tRNA (TRIMs) binding to 40S subunits
  • promoting the association of Met-tRNA and mRNA
  • plays a major role for proper activity of MTOR to regulate skeletal muscle size
  • expression pattern of EIF3F during the cell cycle confirms that this gene is cell division related
  • one of the 13 subunits of the translation initiation factor complex EIF3 required for several steps in the initiation of mRNA translation
  • plays a central role in skeletal muscle size maintenance
    • CELLULAR PROCESS protein, translation/synthesis
    protein, translation regulation
    PHYSIOLOGICAL PROCESS
    text regulation of translational initiation
    PATHWAY
    metabolism
    signaling
    a component
  • component of the EIF3 multiprotein complex 600kDa (composed of at least 13 different subunits)
    • INTERACTION
    DNA
    RNA binding to the 40S ribosome
    small molecule
    protein
  • associates with the complex p170-eIF3
  • interacting with CDK11
  • interacting with FBXO32 (highly conserved C-terminal domain is implicated for FBXO32-directed polyubiquitination and proteasomal degradation)
  • promotes rRNA degradation through direct interaction with heterogeneous nuclear ribonucleoprotein HNRNPK
  • MSH4 interacting protein (EIF3F functions not only in translation but also in the regulation of apoptosis and tumorigenesis)
  • target of the E3 ubiquitin ligase FBXO32 for proteasome-mediated breakdown under atrophic conditions
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS