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FLASH GENE
Symbol EIF3E contributors: mct/npt - updated : 19-02-2019
HGNC name eukaryotic translation initiation factor 3, subunit E
HGNC id 3277
Location 8q23.1      Physical location : 109.213.972 - 109.260.959
Synonym name
  • mammary tumor-associated protein INT6
  • murine mammary tumor integration site 6 (oncogene homolog)
  • mammary tumor-associated protein INT6
  • eukaryotic translation initiation factor 3, subunit 6 48kDa
  • viral integration site protein INT-6 homolog
  • Synonym symbol(s) INT6, EIF3S6, EIF3-P48, eIF3-p46
    DNA
    TYPE functioning gene
    STRUCTURE 46.99 kb     13 Exon(s)
    motif
    MAPPING cloned Y linked N status provisional
    Map cen - D8S1097 - D8S380 - D8S562 - D8S343 - EIF3E - D8S384 - D8S378 - D8S373 - qter
    Authors Miyazaki (97)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1516 - 445 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
     salivary gland   highly
    Endocrineneuroendocrinepituitary   
    Hearing/Equilibriumearinnercochlea highly
    Urinarybladder   highly
    cell lineage
    cell lines Hela cells
    fluid/secretion
    at STAGE
    physiological period embryo
    Text neural crest, notocord, cartilage
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PCI (PINT) proteasome (Int-6, Nip-1, TRIP15) motif
  • HOMOLOGY
    interspecies ortholog to murine Int-6
    Homologene
    FAMILY
  • eukaryotic translation initiation factor family
  • CATEGORY RNA associated , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    basic FUNCTION
  • stabilizing initiator Met tRNA (TRIMs) binding to 40S subunits
  • promoting the association of Met-tRNA and mRNA
  • involved in association with eIF3, in routing specific mRNAs for degradation
  • involved in the quality control of specific mRNAs, the abundance of which is regulated by nonsense-mediated mRNA decay (NMD)
  • stabilizes chromatin-bound MCM7 and alteration of this effect is associated with replication deficiency (Buchsbaum 2007)
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    text regulation of translation
    PATHWAY
    metabolism
    signaling
    a component
  • components of the EIF3 multiprotein complex, 600kDa, subunit (EIF3E) of the eukaryotic translation initiation factor EIF3
  • component of the 26S proteosome
  • component of the COP9 signalosome, 450kDa
  • INTERACTION
    DNA
    RNA binding to the 40S ribosome
    small molecule
    protein
  • EIF3SIP
  • interaction with MCM7 (removal of MCM7 from chromatin as replication proceeds was accelerated in EIF3E-silenced cells and reduced amounts of protein were transiently observed, followed by a correction resulting from stimulation of MCM7 gene expression)(Buchsbaum 2007)
  • EIF4G1 protein binds to EIF3C, EIF3D, and EIF3D to promote mRNA recruitment to the ribosome
  • cell & other
    REGULATION
    Other excluded from PML nuclear bodies by binding to the HTLV-1 oncoprotein
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    of ten deleted in primary breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS