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FLASH GENE
Symbol EIF3D contributors: - updated : 17-08-2007
HGNC name eukaryotic translation initiation factor 3, subunit D
HGNC id 3278
Location 22q13.1      Physical location : 36.906.897 - 36.925.277
Synonym name
  • eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa
  • Synonym symbol(s) EIF3S7, MGC126526, MGC17258, eIF3-p66, eIF3-zeta
    DNA
    TYPE functioning gene
    STRUCTURE 18.00 kb     15 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map cen - D22S277 - CSF2RB - [RAC2 - TST - LGALS1 - D22S283 - D22S1173 ] - MYH9 - APOL2 - D22S426 - D22S272 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     stomach   highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a N terminal RNA binding domain
    HOMOLOGY
    interspecies homolog to murine Mov-34
    Homologene
    FAMILY eukaryotic translation initiation factor family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • stabilizing initiator Met tRNA (TRIMs) binding to 40S subunits
  • promoting the association of Met-tRNA and mRNA, major RNA binding subunit of the complex
  • CELLULAR PROCESS nucleotide, transcription, initiation
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the EIF3 multiprotein, 600kDa, associating with EIF3A
  • INTERACTION
    DNA
    RNA binding to the 40S ribosome
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS