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FLASH GENE
Symbol EIF3C contributors: mct - updated : 19-02-2019
HGNC name eukaryotic translation initiation factor 3, subunit C
HGNC id 3279
Location 16p11.2      Physical location : 28.390.904 - 28.747.048
Synonym name
  • eukaryotic translation initiation factor 3, subunit 8, 110kDa
  • cell migration-inducing protein 17
  • Synonym symbol(s) EIF-p110, EIF3S8, EIF3CL
    DNA
    TYPE functioning gene
    STRUCTURE 47.17 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3063 105.3 913 - 1997 8995409
    21 - 3111 110 913 - 1997 8995409
    21 - 3265 - 913 - 1997 8995409
    20 - 3200 - 913 - 1997 8995409
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Lymphoid/Immunethymus   highly
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PCI (PINT) proteasome int-6, Nip-1, Trip-15, motif
  • HOMOLOGY
    interspecies homolog to S.cerevisiae protein Nip-1
    Homologene
    FAMILY eukaryotic translation initiation factor family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • eukaryotic translation initiation factor, stabilizing initiator Met tRNA (TRIMs) binding to 40S subunits
  • promoting the association of Met-tRNA and mRNA
  • vital to translation initiation, as its downregulation decreases the global protein synthesis and causes a polysome run-off
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the EIF3 multiprotein complex, 600kDa
  • INTERACTION
    DNA
    RNA binding to the 40S ribosome
    small molecule
    protein
  • schwannomin interacting protein (most effective activity for inhibiting cellular proliferation when EIF3C
  • was highly expressed)
  • interacting with EIF3K
  • EIF5-CTD interacts directly with the translation initiation factors EIF1, EIF2S2, and EIF3C, thus forming together with EIF2S2 bound Met-tRNA(i)(Met) the multifactor complex (MFC)
  • dimer of subunits EIF3A and EIF3C serves as a central scaffold to which most of the other subunits bind
  • EIF4G1 protein binds to EIF3C, EIF3D, and EIF3D to promote mRNA recruitment to the ribosome
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in meningiomas, that had lost schwannomin expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target target for treatment of NF2 patient tumors
    ANIMAL & CELL MODELS