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FLASH GENE
Symbol EIF3A contributors: mct - updated : 21-12-2015
HGNC name eukaryotic translation initiation factor 3, subunit A
HGNC id 3271
Location 10q26.11      Physical location : 120.794.541 - 120.840.334
Synonym name
  • eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa
  • centrosomin homolog
  • cytoplasmic protein p167
  • EIF3, p180 subunit
  • Synonym symbol(s) EIF3, EIF3S10, KIAA0139, P167, eIF3-p170, eIF3-theta, p180, p185
    DNA
    TYPE functioning gene
    STRUCTURE 45.79 kb     22 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 5305 166.6 1382 - 2001 11169732
    EXPRESSION
    Rna function mRNA is ubiquitously expressed in all tissues at different levels and is found elevated in a number of cancer types
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Digestiveliver   highly Homo sapiens
     mouthtongue  highly
    Urinarykidney   highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    cell cycle     cell cycle, S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 21 units of an anusual 10 AA repeat
  • a PCI (PINT) proteasome Int-6,Nip-1, Trip-1 motif
  • HOMOLOGY
    interspecies homolog to murine centrosomin B
    Homologene
    FAMILY
  • eukaryotic translation initiation factor family
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    text
  • expression oscillated with cell cycle and peaked in S phase
  • basic FUNCTION
  • role in translation initiation, possibly by acting as an adapter molecule between the translation initiation apparatus and the cytoskeleton structure in the cell
  • stabilizing initiator Met tRNA (TRIMs) binding to 40S subunits
  • may play some roles in development and differentiation and decreased EIF3A expression may be a pre-requisite of intestinal epithelial cell differentiation
  • participating in the initiation process of translation
  • EIF3A-PAIP1 stabilizes the interaction between PABP and EIF4G, which brings about the circularization of the mRNA
  • play an important role in cellular responses to external cell cycle modulators likely by affecting synthesis of target proteins of these modulators
  • may play a role as a regulator of a subset of mRNAs and has been demonstrated to regulate the expression of CDKN1B, tyrosinated alpha-tubulin and ribonucleotide reductase M2 subunit
  • CELLULAR PROCESS nucleotide, transcription, initiation
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    text protein synthesis factor
    PATHWAY
    metabolism
    signaling
    a component
  • component of 800 kDa molecular mass assembly of 13 proteins (EIF3A-EIF3M)
  • INTERACTION
    DNA
    RNA binding to the 40S ribosomal subunit
    small molecule
    protein
  • binding to intermediate filament protein K7 (cytokeratin 7)
  • binding to EIF3B
  • SLBP can interact directly with subunit h of EIF3A and with PAIP1
  • interaction with PAIP1 stabilizes the interaction between PABPC1 and EIF4G, which brings about the circularization of the mRNA
  • PAIP1 act as a translational activator in 5 prime cap-dependent translation by interacting with PABPC1 and the initiation factors EIF4A1 and EIF3A
  • dimer of subunits EIF3A and EIF3C serves as a central scaffold to which most of the other subunits bind
  • RPS6KB1/2 phosphorylate EIF3A to stimulate PAIP1-EIF3A interaction and consequent translation initiation
  • neuron-specific ARHGEF9 interacts with EIF3A, and its binding partner GPHN associates with MTOR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in breast, cervical, esophageal and stomach carcicomas
    tumoral     --over  
    P150 activated in several cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS