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FLASH GENE
Symbol EIF2S2 contributors: mct - updated : 19-02-2019
HGNC name eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
HGNC id 3266
Location 20q11.22      Physical location : 32.676.116 - 32.700.085
Synonym name eukaryotic initiation factor 2-beta
Synonym symbol(s) EIF2, EIF2B, MGC8508, DKFZp686L18198, PPP1R67, eIF-2-beta
DNA
TYPE functioning gene
STRUCTURE 24.06 kb     9 Exon(s)    4 Copie(s)
10 Kb 5' upstream gene genomic sequence study
text structure
  • four copies in the genome but only one contains the entire cDNA sequence and introns
  • promoter has one Pal binding site (for transcriptional regulation by alpha-pal transcription factor)
  • MAPPING cloned Y linked N status provisional
    Physical map
    C20orf70 20q11.21 chromosome 20 open reading frame 70 SOCS2P1 20 suppressor of cytokine signaling 2 pseudogene 1 BASE 20q11.21 suppressor of cytokine signaling 2 pseudogene 1 C20orf71 20q11.22 chromosome 20 open reading frame 71 PLUNC 20p11.1-q12 palate, lung and nasal epithelium carcinoma associated RPL12P3 20q11.21 ribosomal protein L12 pseudogene 3 C20orf114 20q11.23 chromosome 20 open reading frame 114 CDK5RAP1 20pter-q11.23 CDK5 regulatory subunit associated protein 1 SNTA1 20q11.2 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) CBFA2T2 20q11.21-q11.23 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 APBA2BP 20q11.21 amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein C20orf144 20q11.21 chromosome 20 open reading frame 144 E2F1 20q11 E2F transcription factor 1 PXMP4 20q11.21 peroxisomal membrane protein 4, 24kDa ZNF341 20q11.21 zinc finger protein 341 RPL31P2 20q11.2 ribosomal protein L31 pseudogene 2 C20orf178 20q11.22 chromosome 20 open reading frame 178 TPM5P 20q11.2 tropomyosin 5, pseudogene RALY 20q11.21-q11.23 RNA binding protein (autoantigenic, hnRNP-associated with lethal yellow) EIF2S2 20pter-q12 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa LOC391244 20 similar to ribosomal protein S2; 40S ribosomal protein S2 XPOTP1 20q11.21 exportin, tRNA (nuclear export receptor for tRNAs) pseudogene 1 ASIP 20q11.21 agouti signaling protein, nonagouti homolog (mouse) AHCY 20cen-q13.1 S-adenosylhomocysteine hydrolase ITCH 20q11.22-23 itchy homolog E3 ubiquitin protein ligase (mouse) CDC42P1 20q11.22 cell division cycle 42 pseudogene 1 FDXP1 20cen-q13.1 ferredoxin pseudogene 1 FLJ38773 20q11.22 hypothetical protein FLJ38773 DNCL2A 20q12-q13.1 dynein, cytoplasmic, light polypeptide 2A MAP1LC3A 20cen-q13 microtubule-associated protein 1 light chain 3 alpha CDC91L1 20q11.21 CDC91 cell division cycle 91-like 1 (S. cerevisiae) NCOA6 20q11 nuclear receptor coactivator 6 HMG4L 20q11.21 high-mobility group (nonhistone chromosomal) protein 4-like GGTL3 20pter-p13 gamma-glutamyltransferase-like 3 ACAS2 20q11.2-q12 acetyl-Coenzyme A synthetase 2 (ADP forming)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2592 38.26 333 - 2016 26609049
    9 - 2688 - 330 - 2016 26609049
    8 - 2640 - 314 - 2016 26609049
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a highly charged N terminal region composed of three basic polylysine blocks separated by acidic domains
  • putative GTP binding sites
  • a zinc finger motif
  • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to C.elegans K04G2.1
    Homologene
    FAMILY
  • EIF2 beta/EIF5 family
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • functions as a transcription initiation factor
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterotrimer composed of an alpha, beta and a gamma chain
  • INTERACTION
    DNA
    RNA
  • binding to initiator tRNA
  • binding to 40S ribosomal subunit
  • small molecule
    protein
  • binding to 40S ribosomal subunit
  • EIF5-CTD interacts directly with the translation initiation factors EIF1, EIF2S2, and EIF3C, thus forming together with EIF2S2 bound Met-tRNA(i)(Met) the multifactor complex (MFC)
  • role of EIF5-CTD dynamic interplay with EIF1 and EIF2S2 in switching PICs from an open to a closed state at start codons
  • addition of CXCL12 leads to the dissociation of EIF2S2 from CXCR4 suggesting that stimulation of the receptor may trigger the local protein synthesis required for efficient cell movement
  • importance of EIF5 GDI (GDP-dissociation inhibitor) activity, and EIF2S2 acts in concert with EIF5 to prevent premature release of GDP from EIF2S3 and thereby ensure tight control of protein synthesis initiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification --over  
    in lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    is a therapeutic target for lung cancer
    ANIMAL & CELL MODELS