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FLASH GENE
Symbol EIF2S2 contributors: mct - updated : 19-02-2019
HGNC name eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
HGNC id 3266
Location 20q11.22      Physical location : 32.676.116 - 32.700.085
Synonym name eukaryotic initiation factor 2-beta
Synonym symbol(s) EIF2, EIF2B, MGC8508, DKFZp686L18198, PPP1R67, eIF-2-beta
DNA
TYPE functioning gene
STRUCTURE 24.06 kb     9 Exon(s)    4 Copie(s)
10 Kb 5' upstream gene genomic sequence study
text structure
  • four copies in the genome but only one contains the entire cDNA sequence and introns
  • promoter has one Pal binding site (for transcriptional regulation by alpha-pal transcription factor)
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2592 38.26 333 - 2016 26609049
    9 - 2688 - 330 - 2016 26609049
    8 - 2640 - 314 - 2016 26609049
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a highly charged N terminal region composed of three basic polylysine blocks separated by acidic domains
  • putative GTP binding sites
  • a zinc finger motif
  • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to C.elegans K04G2.1
    Homologene
    FAMILY
  • EIF2 beta/EIF5 family
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • functions as a transcription initiation factor
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterotrimer composed of an alpha, beta and a gamma chain
  • INTERACTION
    DNA
    RNA
  • binding to initiator tRNA
  • binding to 40S ribosomal subunit
  • small molecule
    protein
  • binding to 40S ribosomal subunit
  • EIF5-CTD interacts directly with the translation initiation factors EIF1, EIF2S2, and EIF3C, thus forming together with EIF2S2 bound Met-tRNA(i)(Met) the multifactor complex (MFC)
  • role of EIF5-CTD dynamic interplay with EIF1 and EIF2S2 in switching PICs from an open to a closed state at start codons
  • addition of CXCL12 leads to the dissociation of EIF2S2 from CXCR4 suggesting that stimulation of the receptor may trigger the local protein synthesis required for efficient cell movement
  • importance of EIF5 GDI (GDP-dissociation inhibitor) activity, and EIF2S2 acts in concert with EIF5 to prevent premature release of GDP from EIF2S3 and thereby ensure tight control of protein synthesis initiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification --over  
    in lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    is a therapeutic target for lung cancer
    ANIMAL & CELL MODELS