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FLASH GENE
Symbol EIF1AX contributors: - updated : 10-04-2006
HGNC name eukaryotic translation initiation factor 1A, X-linked
HGNC id 3250
Location Xp22.1      Physical location : 20.142.636 - 20.159.966
Synonym name
  • eukaryotic translation initiation factor 1A, X chromosome
  • eukaryotic translation initiation factor 1A
    • Synonym symbol(s) EIF1A, EIF4C, eIF-1A, eIF-4C
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text escaping X inactivation
    STRUCTURE 17.00 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an unblocked N terminal proline
  • one S1-like domain
    • mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Eif1ay
    Homologene
    FAMILY EIF1A family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • enhancing ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits
  • required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNA eIF3) to the 5'end of capped mRNA
    • CELLULAR PROCESS protein, translation regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    translation initiation pathway
    a component of the eukaryotic translation initiation factor 4F complex
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein initiation factor EIF5B
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS