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FLASH GENE
Symbol EID2 contributors: mct - updated : 07-05-2020
HGNC name EP300 interacting inhibitor of differentiation 2
HGNC id 28292
Location 19q13.2      Physical location : 40.029.448 - 40.030.838
Synonym name
  • hypothetical protein MGC20452
  • CREBBP/EP300 inhibitory protein 2
  • E1A like inhibitor of differentiation 2
  • Synonym symbol(s) EID-2, MGC20452, CRI2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 1.46 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1455 - 236 - 2005 15970276
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrineparathyroid   highly
    Nervousbrain   highly
    Reproductivemale systemprostate   
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text in the developing spinal cord and brain structures and continues in neonatal and adult brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one formin homology 1 (fh1) domain
  • two formin homology 2 (fh2) domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Cri2
    intraspecies homolog to CRI1
    Homologene
    FAMILY
  • EID family
  • formin homology family
  • cappuccino subfamily
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • carboxypeptidase A activity
  • may function as an endogenous suppressor of TGF-beta signaling
  • negatively regulating differentiation through a p300-dependent mechanism
  • EID2 inhibited MYOD-dependent transcription and muscle differentiation
  • EID1, EID2 were identified as negative regulators of cellular differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • EID3 formed a homodimer or heterodimer with EID2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • N-terminal portion of EID2 was required for the binding to HDACs
  • EID2-MAGEC2 interaction, and N-terminal extension of the EID2 binding domain took part in the EID2-MAGEC2 interaction
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS