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Symbol EHD3 contributors: mct - updated : 08-12-2015
HGNC name EH-domain containing 3
HGNC id 3244
Location 2p23.1      Physical location : 31.456.879 - 31.491.259
Synonym name EPS15 homology (EH) domain family member 3
Synonym symbol(s) PAST3, EHD2
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 34.06 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
FOSL2 2p23-p22 FOS-like antigen 2 FLJ23306 2p23.3 hypothetical protein FLJ23306 LOC388937 2 similar to Phospholipase PLB PPP1CB 2p23 protein phosphatase 1, catalytic subunit, beta isoform SPY1 2p23.3 speedy FLJ20628 2p23.3 hypothetical protein FLJ20628 KIAA0007 2p23.3 KIAA0007 protein LOC388938 2 LOC388938 LOC165186 2p23.3 similar to RIKEN cDNA 4632412N22 gene LOC388939 2 similar to BC027072 protein FLJ21069 2p23.3 hypothetical protein FLJ21069 ALK 2p23 anaplastic lymphoma kinase (Ki-1) CGI-127 2p23.3 yippee protein LBH 2p23.3 likely ortholog of mouse limb-bud and heart gene FLJ37965 CAPN13 2p22-p21 likely ortholog of mouse limb-bud and heart gene GALNT14 2p23.2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) EHD3 2p21.1 EH-domain containing 3 LOC391361 2 similar to ribosomal protein L21 XDH 2p23-p22.2 xanthine dehydrogenase SRD5A2 2p23 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) LOC391362 2 similar to human alpha-catenin LOC339736 2p23.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) CGI-27 2p23.2 C21orf19-like protein LOC84661 2p23.2 dpy-30-like protein SPG4 2p22-p21 spastic paraplegia 4 (autosomal dominant; spastin) SLC30A6 2p22.3 solute carrier family 30 (zinc transporter), member 6 RH-II/GuBp1 2p22-p21 RH-II/GuB pseudogene 1 CARD12 2p22-p21 caspase recruitment domain family, member 12 MGC11061 2p23.2 hypothetical protein MGC11061 BIRC6 2p22-p21 baculoviral IAP repeat-containing 6 (apollon) FLJ20272 2p23.2-p23.1 hypothetical protein FLJ20272 LOC391363 2 similar to Latent transforming growth factor beta binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1 binding protein 1) (TGF-beta1-BP-1) LTBP1 2p22-p21 latent transforming growth factor beta binding protein 1 RASGRP3 2p25.1-p24.1 RAS guanyl releasing protein 3 (calcium and DAG-regulated) DKFZP564F0522 2p23.1 DKFZP564F0522 protein LOC391364 2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC151325 2p23.1 similar to hypothetical protein BC013995 LOC344371 2p23.1 similar to ADP,ATP carrier protein, fibroblast isoform (ADP/ATP translocase 2) (Adenine nucleotide translocator 2) (ANT 2)
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3906 - 535 - 2007 17507647
Type widely
   expressed in (based on citations)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveesophagus   highly
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunelymph node   highly
Urinarykidney   moderately
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal   Homo sapiens
cell lineage
cell lines
physiological period pregnancy
Text placenta
  • an EPS15 (EH) protein binding domain
  • an EF hand (Ca2+ binding) motif at C terminus
    interspecies ortholog to rattus Ehd3
    intraspecies paralog to EHD1, EHD2, EHD4
  • Eps15 homology domain-containing protein family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
  • EHD1 and EHD3 localize to preciliary membranes and the ciliary pocket
  • resides in tubular and vesicular membrane structures and participates in endocytic recycling
  • basic FUNCTION
  • participating in the clathrin-mediated endocytic machinery
  • also potentially involved in signal transduction pathways, downsteam of receptor tyrosine kinases
  • regulates microtubule-dependent movements of endocytic tubular ans vesicular structures
  • having a function in early endosome to endocytic recycling compartment transport
  • regulates transport from the early endosome to the recycling endosome (George 2007)
  • colocalize with vesicular and tubular structures, implying roles in transport processes and cytoskeletal dynamics and interact with specific phospholipids (Blume 2007)
  • role for EHD3 in regulating endosome-to-Golgi transport, and as a consequence, lysosomal biosynthetic, but not secretory, transport pathways are also affected
  • critical mediator of membrane protein trafficking in the heart
  • is a previously unrecognized component of the cardiac remodeling pathway
  • the functions of both EHD1 and EHD4 are primarily in tubular recycling endosomes (TREs) membrane vesiculation, whereas EHD3 is a membrane-tubulating protein
  • functions as a tumor suppressor gene and loss of its expression is a very common event in gliomas
  • is a critical component of protein trafficking in heart and is essential for the proper membrane targeting of select cellular proteins that maintain excitability
  • EHD1 and EHD3 reorganize the M-centriole and associated distal appendage vesicles (DAVs) before coordinated ciliary membrane and axoneme growth
  • CACNA1G, CACNA1H are substrates for EHD3-dependent protein trafficking in heart, implicating EHD3 as a key player in the regulation of atrial myocyte excitability and cardiac conduction
  • EHD1 and EHD3 control traffic to the endocytic recycling compartment (ERC) and from the ERC to the plasma membrane, while EHD2 modulates internalization
    a component
    small molecule metal binding, nucleotide,
  • ATP/GTP binding
  • ions Ca2+ binding
  • protein
  • associating with the AP2 adaptor protein complex to initiate endocytic vesicle formation
  • interacting with EHD1
  • interacting with SNAP29
  • cell & other
    Other SUMOylation of EHD3 is involved in tubulation of the ERC membranes, which is important for efficient recycling
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gliomas, including low-grade astrocytomas
    Variant & Polymorphism
    Candidate gene
    Therapy target