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Symbol EHD1 contributors: mct/npt/pgu - updated : 09-12-2015
HGNC name EH-domain containing 1
HGNC id 3242
Location 11q13.1      Physical location : 64.620.207 - 64.646.191
Synonym name
  • testilin
  • PAST homolog 1
  • Synonym symbol(s) PAST1, PAST, HPAST1, FLJ42622, FLJ44618
    TYPE anonymous DNA segment
    STRUCTURE 25.98 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    RPS6KA4 11q11-q13 ribosomal protein S6 kinase, 90kDa, polypeptide 4 LOC387777 11 LOC387777 FLJ37045 11q13.1 hypothetical protein FLJ37045 SLC22A11 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 11 SLC22A12 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 12 NRXN2 11q13.2 neurexin 2 RASGRP2 11q13 RAS guanyl releasing protein 2 (calcium and DAG-regulated) PYGM 11q13.2 phosphorylase, glycogen; muscle (McArdle syndrome, glycogen storage disease type V) SF1 11q13.2 splicing factor 1 MAP4K2 11q13 mitogen-activated protein kinase kinase kinase kinase 2 MEN1 11q13.2 multiple endocrine neoplasia I HSMDPKIN 11q13 multiple endocrine neoplasia I EHD1 11q13 EH-domain containing 1 KIAA0404 11q13.3-q13.5 EH-domain containing 1 PPP2R5B 11q13 protein phosphatase 2, regulatory subunit B (B56), beta isoform GPHA2 11q13.1 glycoprotein hormone alpha 2 LOC283129 11q13.1 hypothetical protein LOC283129 LOC116071 11q13.1 hypothetical protein BC012330 SNX15 11q12 sorting nexin 15 ARL2 11q13 ADP-ribosylation factor-like 2 LOC390210 11 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) HSU79266 11q13.1 protein predicted by clone 23627 NAALADL1 11q12 N-acetylated alpha-linked acidic dipeptidase-like 1 LOC256676 11q13.1 hypothetical LOC256676 CDCA5 11q12.1 cell division cycle associated 5 ZFPL1 11q13 zinc finger protein-like 1 C11orf2 11q13 chromosome 11 open reading frame2 TM7SF2 11q13 transmembrane 7 superfamily member 2 C11orf5 11q13 chromosome 11 open reading frame 5 FAU 11q12-q13.1 Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30 MRPL49 11q13 mitochondrial ribosomal protein L49 HRD1 11q13 HRD1 protein
    TRANSCRIPTS type messenger
    text smaller form, testis specific (PMID: 10395801)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3482 60.8 534 widely 2008 18661112
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     spleen   highly
    Nervousbrain   highly
    Reproductivefemale systemplacenta  highly
     male systemtestis  highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal   Homo sapiens
    cell lineage
    cell lines
    at STAGE
  • an N-terminal ATPase domain
  • a highly conserved ATP/GTP binding domain
  • a central coiled-coil structure
  • a EPS15 (EH) domain including an EF hand-Ca2 binding motif at the C terminus, involved in targeting EPS15 into clathrin-coated pits,
  • a C-terminal nucleotide-binding motif
  • a central coiled-coil involved in oligomerization
  • C-terminal EH domain binding to proteins containing either an Asn-Pro-Phe or Asp-Pro-Phe motif, and playing an important role in the subcellular localization and function
  • conjugated PhosphoP
    interspecies homolog to murine Dres134 (expressed in embryonic CNS,PNS,retina and gut,testilin)
    homolog to Drosophila past testilin
    ortholog to murine Ehd1
    intraspecies paralog to EHD3, EHD2, EHD4
  • EPS15 homology (EH) domain family
  • C-terminal Eps15 homology domain (EH) containing protein family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
  • EHD1 and EHD3 localize to preciliary membranes and the ciliary pocket
  • basic FUNCTION
  • potentially participating as a down-regulator, in clathrin-coated pit-mediated endocytosis of IGF1 receptor after binding to its ligand
  • implicated in the recycling of internalized proteins to the plasma membrane
  • ZFYVE20 and EHD1 may act sequentially in the transport of proteins from early endosomes to the endosomal recycling compartment and back to the plasma membrane
  • regulate the exit of cargo from the recycling endosome
  • colocalize with vesicular and tubular structures, implying roles in transport processes and cytoskeletal dynamics and interact with specific phospholipids
  • also potentially involved in signal transduction pathways, downstream of receptor tyrosine kinases
  • functions in the recycling of membrane proteins from recycling endosomes to plasma membrane
  • play a critical role in the recycling of plasma membrane receptors (i.e., transferrin) that are internalized either through clathrin-coated pits or independently of clathrin
  • may impact the storage of esterified cholesterol in the organelles (lipid droplets)
  • phosphorylation occuring between early endosomes and endocytic recycling compartment
  • may be playing a role in the endocytosis of IGF1 receptors
  • plays an important role in regulating beta1 integrin transport, and required in integrin-mediated downstream functions
  • key regulator of endocytosis and associates with tubular membranes to facilitate recycling
  • affects the coupling of synaptotagmin-1 to the SNARE complex, and could be a negative regulator of exocytosis
  • synaptic protein that negatively affects exocytosis through binding to SNAPIN
  • regulates the trafficking of multiple receptors from the endocytic recycling compartment (ERC) to the plasma membrane
  • role for EHD1 in regulating the trafficking of CD59, an endogenous GPI-AP, at early stages of trafficking through the endocytic pathway
  • functions in the recycling endosome and is required for endosome-to-plasma membrane transport of multiple cargos
  • in neurons, EHD1 functions in early endosomes rather than (or possibly in addition to) recycling endosomes
  • EHD proteins and ferlin proteins form discrete structures in myoblasts
  • enriched at synaptic release sites, suggesting a possible involvement in the trafficking of synaptic vesicles
  • PLA2G4A and EHD1 are involved in the vesiculation of CD59-containing endosomes
  • the functions of both EHD1 and EHD4 are primarily in tubular recycling endosomes (TREs) membrane vesiculation, whereas EHD3 is a membrane-tubulating protein
  • EHD1 and EHD3 reorganize the M-centriole and associated distal appendage vesicles (DAVs) before coordinated ciliary membrane and axoneme growth
  • EHD1 and EHD3 control traffic to the endocytic recycling compartment (ERC) and from the ERC to the plasma membrane, while EHD2 modulates internalization
    a component
    small molecule metal binding, nucleotide,
  • ATP/GTP binding
  • ions Ca2+ binding
  • protein
  • interacting with SNAP29 and associating with the AP2 adaptor protein complex to initiate endocytic vesicle formation
  • interacting with EHD3
  • interacting with IGF1-R
  • interaction with Rab11 effector protein, Rab11-FIP2, suggesting that EHD1 regulates the transport of Rab11-FIP2-and Rab11-containing vesicles
  • interacts with a synaptic protein, snapin
  • FER1L5 binds directly to the endocytic recycling proteins EHD1 and EHD2 and the second C2 domain in FER1L5 mediates this interaction
  • ANKFY1 is an interaction partner for the recycling regulatory protein EHD1
  • ARF35 regulates the formation of an EHD1-association site on ARF6-positive endosomes by integrating the functions of two distinct RAB35 effectors for successful neurite outgrowth
  • cell & other
    Other ATP-binding is required for oligomerization