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FLASH GENE

Symbol

EGR3

contributors: mct/pgu - updated : 09-04-2013

HGNC name	early growth response 3
HGNC id	3240

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8p21.3      Physical location : 22.545.173 - 22.550.815
Synonym symbol(s)	PILOT

DNA

TYPE	functioning gene
STRUCTURE	5.64 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004430 2 - 4342 NP_004421 - 387 - 2005 16091474 NM_001199881 2 - 3912 NP_001186810 - 333 - 2005 16091474 NM_001199880 2 - 3918 NP_001186809 - 349 - 2005 16091474

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Endocrine neuroendocrine pituitary     highly Hearing/Equilibrium ear inner cochlea   highly Nervous brain diencephalon hypothalamus suprachiasmatic nuclei     brain         Mus musculus Respiratory lung         Skin/Tegument skin       highly

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell Nervous neuron Mus musculus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

zinc finger protein, class I with three zinc fingers

HOMOLOGY

interspecies	ortholog to murine Egr3
	homolog to Drosophila sr
	homolog to C.elegans C27C12.2

intraspecies

homolog to EGR1,EGR2

Homologene

FAMILY	early growth response 3 family
	EGR family of C2H2-type zinc-finger proteins

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	may be a critical regulator of endogenous GABRA4 during development
	may also plays a role in muscle development
	transcriptional regulator, essential for normal hippocampal long-term potentiation (LTP) and for hippocampal and amygdala dependent learning and memory
	has an essential role in learning and memory processing that appears to be partly distinct from the role of EGR1
	EGR1, EGR2, EGR3, are essential for conversion of the mitogenic signal of epidermal growth factor into a proliferative response
	is a critical determinant of VEGF signaling in activated endothelial cells
	transcription factor regulated by NGF signaling in sympathetic neurons that is essential for normal SNS development
	role for Egr3 in mediating sympathetic target tissue innervation that is independent of neuron survival or neurotrophin deregulation
	EGR2 and EGR3 regulate B and T cell function in adaptive immune responses and homeostasis by promoting antigen receptor signaling and controlling inflammation
	nerve growth factor (NGF)-induced transcriptional regulator that is essential for normal sympathetic nervous system development
	has an essential role in regulating sympathetic neuron dendrite morphology and terminal axon branching, but not in regulating sympathetic axon guidance to their targets
	EGR2 and EGR3 are the unique regulators for systemic autoimmunity

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

circadian , development

text	muscle development

PATHWAY

metabolism

signaling

calcineurin signaling pathway

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	zinc Zn2+

protein	binding GABRA4
	downstream target for calcineurin
	BDNF uses CREB1 and EGR3 to regulate NMDA receptor levels in cortical neurons

cell & other

REGULATION

activated by

light in the ventral SCN,a structure implicated to "entrainment",i.e the precise adaptation to the 24hlight-dark cycle

induced by	DAG1 and AGRN (AGRN with lamin and DAG1, influence EGR3 levels and therefore may play an important role in spindle fiber differentiation)
		NRG1, that induces expression of the muscle spindle-specific gene EGR3 by stimulating the transcriptional activity of CREB1 and SRF

Other

suppressed by cyclosporin A in T cells

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to schizophrenia

Variant & Polymorphism SNP	increasing the risk of schizophrenia

Candidate gene	for schizophrenia pathogenesis
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous vascular   represents a potential therapeutic target in VEGF-mediated vasculopathic diseases

ANIMAL & CELL MODELS

	sensory ataxia and muscle spindle (encapsulated muscle fibers conservated by specialized motor and sensory axons) agenesis,suggesting that type I myotubes are dependent upon Egr3 mediated transcription for proper spindle development
	germline Egr3-deficient mice have physiologic dysautonomia characterized by apoptotic sympathetic neuron death and abnormal innervation to many target tissues