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FLASH GENE
Symbol EGR3 contributors: mct/pgu - updated : 09-04-2013
HGNC name early growth response 3
HGNC id 3240
Location 8p21.3      Physical location : 22.545.173 - 22.550.815
Synonym symbol(s) PILOT
DNA
TYPE functioning gene
STRUCTURE 5.64 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
GFRA2 8p22-p21 GDNF family receptor alpha 2 DOK2 8p21.2 docking protein 2, 56kDa XPO7 8p21 exportin 7 NPM2 8p21.3 nucleophosmin/nucleoplasmin, 2 FGF17 8p21 fibroblast growth factor 17 EPB49 8p21.1 erythrocyte membrane protein band 4.9 (dematin) RAI16 8p21.2 retinoic acid induced 16 FLJ22494 8p21.3 hypothetical protein FLJ22494 HR 8p22-p21 hairless homolog (mouse) FLJ22246 8p21.3 hypothetical protein FLJ22246 LGI3 8p21.2 leucine-rich repeat LGI family, member 3 SFTPC 8p21.2 surfactant, pulmonary-associated protein C BMP1 8p21.2 bone morphogenetic protein 1 PHYHIP 8p21.2 phytanoyl-CoA hydroxylase interacting protein POLR3D 8q21 polymerase (RNA) III (DNA directed) polypeptide D, 44kDa PIWIL2 8p21.2 piwi-like 2 (Drosophila) SLC39A14 8p21.2 solute carrier family 39 (zinc transporter), member 14 PPP3CC 8p21.2 protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma) LOC389639 8 LOC389639 SCAM-1 8p21.2 vinexin beta (SH3-containing adaptor molecule-1) PDLIM2 8p21.2 PDZ and LIM domain 2 (mystique) DBC-1 8p22 p30 DBC protein BIN3 8p21.2 bridging integrator 3 FLJ14107 8p21.2 hypothetical protein FLJ14107 EGR3 8p23-p21 early growth response 3 MGC22776 8p21.2 hypothetical protein MGC22776 RHOBTB2 8p21.2 Rho-related BTB domain containing 2 TNFRSF10B 8p21 tumor necrosis factor receptor superfamily, member 10b LOC389640 8 LOC389640 TNFRSF10C 8p21 tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain TNFRSF10D 8p21 tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain TNFRSF10A 8p21 tumor necrosis factor receptor superfamily, member 10a LOC389641 8 hypothetical gene supported by AK124295 MGC29816 8p21.2 hypothetical protein MGC29816 LOC203069 8p21.2 hypothetical protein LOC203069 LOXL2 8p21.3-p21.2 lysyl oxidase-like 2 LYSAL1 8p22-p21.3 lysosomal apyrase-like 1 MSCP 8p21.2 mitochondrial solute carrier protein PRO1496 8p21.2 hypothetical protein PRO1496
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 4342 - 387 - 2005 16091474
2 - 3912 - 333 - 2005 16091474
2 - 3918 - 349 - 2005 16091474
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrineneuroendocrinepituitary  highly
Hearing/Equilibriumearinnercochlea highly
Nervousbraindiencephalonhypothalamussuprachiasmatic nuclei 
 brain     Mus musculus
Respiratorylung    
Skin/Tegumentskin   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
Nervousneuron Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
zinc finger protein, class I with three zinc fingers
HOMOLOGY
interspecies ortholog to murine Egr3
homolog to Drosophila sr
homolog to C.elegans C27C12.2
intraspecies homolog to EGR1,EGR2
Homologene
FAMILY
  • early growth response 3 family
  • EGR family of C2H2-type zinc-finger proteins
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may be a critical regulator of endogenous GABRA4 during development
  • may also plays a role in muscle development
  • transcriptional regulator, essential for normal hippocampal long-term potentiation (LTP) and for hippocampal and amygdala dependent learning and memory
  • has an essential role in learning and memory processing that appears to be partly distinct from the role of EGR1
  • EGR1, EGR2, EGR3, are essential for conversion of the mitogenic signal of epidermal growth factor into a proliferative response
  • is a critical determinant of VEGF signaling in activated endothelial cells
  • transcription factor regulated by NGF signaling in sympathetic neurons that is essential for normal SNS development
  • role for Egr3 in mediating sympathetic target tissue innervation that is independent of neuron survival or neurotrophin deregulation
  • EGR2 and EGR3 regulate B and T cell function in adaptive immune responses and homeostasis by promoting antigen receptor signaling and controlling inflammation
  • nerve growth factor (NGF)-induced transcriptional regulator that is essential for normal sympathetic nervous system development
  • has an essential role in regulating sympathetic neuron dendrite morphology and terminal axon branching, but not in regulating sympathetic axon guidance to their targets
  • EGR2 and EGR3 are the unique regulators for systemic autoimmunity
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS circadian , development
    text muscle development
    PATHWAY
    metabolism
    signaling
    calcineurin signaling pathway
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • binding GABRA4
  • downstream target for calcineurin
  • BDNF uses CREB1 and EGR3 to regulate NMDA receptor levels in cortical neurons
  • cell & other
    REGULATION
    activated by light in the ventral SCN,a structure implicated to "entrainment",i.e the precise adaptation to the 24hlight-dark cycle
    induced by DAG1 and AGRN (AGRN with lamin and DAG1, influence EGR3 levels and therefore may play an important role in spindle fiber differentiation)
    NRG1, that induces expression of the muscle spindle-specific gene EGR3 by stimulating the transcriptional activity of CREB1 and SRF
    Other suppressed by cyclosporin A in T cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia
    Variant & Polymorphism SNP increasing the risk of schizophrenia
    Candidate gene for schizophrenia pathogenesis
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneousvascular 
    represents a potential therapeutic target in VEGF-mediated vasculopathic diseases
    ANIMAL & CELL MODELS
  • sensory ataxia and muscle spindle (encapsulated muscle fibers conservated by specialized motor and sensory axons) agenesis,suggesting that type I myotubes are dependent upon Egr3 mediated transcription for proper spindle development
  • germline Egr3-deficient mice have physiologic dysautonomia characterized by apoptotic sympathetic neuron death and abnormal innervation to many target tissues