basic FUNCTION
| acting as a regulator of hypoxia-inducible factor HIF, alpha-1 subunit by prolylhydroxylation and targeting it to proteasome degradation |
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playing a role during the differentiation (when is overexpressed) |
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contributing in a non-redundant manner to the regulation of both HIF-1alpha and HIF-2alpha subunits |
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catalyzing hydroxylation of the alpha subunit of hypoxia-inducible factor-alpha |
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stabilizing myogenin protein |
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playing a role in regulating skeletal muscle differentiation |
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central regulator of the molecular responses to oxygen availability (Rantanen 2008) |
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expressed in response to hypoxia and causes apoptosis in oxygenated conditions in neural cells (Rantanen 2008) |
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may hydroxylate divergent substrates and/or connect divergent cellular responses with HIF (Hopfer 2006) |
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plays an important role in neuronal apoptosis (Schlisio 2008) |
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negative regulator of NFKappaB, potentiating myogenic differentiation (Fu 2010) |
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EGLN2, EGLN3 control the transactivation activity of ATF4 |
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is a critical determinant of glioma formation and tumor vascular functionality |
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with EGLN1, EGLN2 are cellular oxygen sensors that can mark HIF1A for von Hippel-Lindau protein-mediated proteasomal destruction |
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under normoxia, has been shown to be proapoptotic, but under hypoxia, it can have cell survival or proliferation-supporting functions |
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negative regulator of the NFKB pathway |
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negatively regulates the canonical NFKB1 pathway |
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important role for EGLN1, EGLN3 as mediators of islet insulin secretion |