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Symbol EGF contributors: mct/ - updated : 08-04-2011
HGNC name epidermal growth factor
HGNC id 3229
Corresponding disease
HOMG4 hypomagnesemia, renal
Location 4q25      Physical location : 110.834.039 - 110.934.117
Synonym name
  • urogastrone
  • epidermal growth factor (beta-urogastrone)
  • pro-epidermal growth factor
  • Synonym symbol(s) URG, HOMG4
    TYPE functioning gene
    STRUCTURE 100.08 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure cis-regulatory elements with a Y-box sequence 5' - CTGATTGG - 3'
    MAPPING cloned Y linked Y status confirmed
    Physical map
    PAPSS1 4q24 3'-phosphoadenosine 5'-phosphosulfate synthase 1 MGC26963 4q25 hypothetical protein MGC26963 LOC113612 HADHSC 4q22-q26 L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain LEF1 4q23-q25 lymphoid enhancer-binding factor 1 LOC389215 4 LOC389215 LOC339979 4q25 similar to ligand-gated ion channel subunit LOC391681 4 similar to rexo70 FLJ37673 4q25 hypothetical protein FLJ37673 RPL34 4q24 ribosomal protein L34 DC2 4q25 DC2 protein AGXT2L1 4q25 alanine-glyoxylate aminotransferase 2-like 1 LOC391682 4 similar to RCC1-like COL25A1 4q25 collagen, type XXV, alpha 1 LOC389216 4 similar to heterogeneous nuclear ribonucleoprotein G - human SEC24B 4q24 SEC24 related gene family, member B (S. cerevisiae) LOC389217 4 similar to template acyivating factor-I alpha FLJ20647 4q25 hypothetical protein FLJ20647 CASP6 4q25 caspase 6, apoptosis-related cysteine protease PLA2G12 4q25 phospholipase A2, group XII IF 4q25 I factor (complement) NOLA1 4q28-q31.1 nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs) RRH 4q retinal pigment epithelium-derived rhodopsin homolog FLJ44691 4q25 FLJ44691 protein LOC391683 4 similar to keratin 19; keratin, type I cytoskeletal 19; keratin, type I, 40-kd; cytokeratin 19; 40-kDa keratin intermediate filament precursor gene EGF 4q25 epidermal growth factor (beta-urogastrone) ELOVL6 4q25 ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) LOC132706 4q25 similar to heat shock factor binding protein 1 LOC132707 4q25 similar to Ac-like transposable element; putative Ac-like transposon; zinc finger, BED domain containing 1 LOC391684 4 similar to ribosomal protein L7-like 1 LOC391685 4 similar to KIAA2033 protein ENPEP 4q25 glutamyl aminopeptidase (aminopeptidase A) PITX2 4q25-q27 paired-like homeodomain transcription factor 2 LOC391686 4 similar to lysophospholipase I; lysophospholipase 1; lysophospholipid-specific lysophospholipase; acyl-protein thioesterase-1 LOC132719 4q25-q26 similar to beta-tubulin 4Q LOC391687 4 similar to ribosomal protein S12 FLJ39370 4q26 hypothetical protein FLJ39370 PRO0971 4q26 hypothetical protein PRO0971 T2BP 4q26 TRAF2 binding protein LAK 4q26 lymphocyte alpha-kinase
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 5477 - 1166 - 1995 7640657
    23 - 5474 - 1165 - 1995 7640657
    24 - 5600 2.4 1207 - 1995 7640657
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestineduodenum  
     salivary glandsubmandibular   
    Nervousspinal cord   highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney   highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    at STAGE
  • containing nine EGF-like repeats
  • nine LDL-receptor class b repeats
  • conjugated GlycoP
    isoforms Precursor mature peptide of 53AA
  • epidermal growth factor family
  • CATEGORY signaling cytokine growth factor
        plasma membrane
    text precursor membrane bound
    basic FUNCTION
  • regulator of cell proliferation
  • plays a crucial role in mitogenic regulation of human brain tumor stem cells
  • differentiation of specific cells and mitogenic factor for cells of ectodermal and mesodermal origin
  • antagonistically involved in both PTK2 phosphorylation and dephosphorylation with different mechanisms in a cell
  • EGF and FGF2, may play an important role in the fate decision of neural crest progenitors and in the development of the peripheral nervous system
  • activates ERBB1/ERBB1 or ERBB1/ERBB2 dimers
  • caspase-8 is necessary for the efficient activation of downstream events associated with epidermal growth factor (EGF) signaling
  • EGF with nucleotides carry the potential to act synergistically in the control of cell proliferation and cell survival in adult neurogenesis
  • EGF and TGFA retain some level of functional redundancy, possibly resulting from their divergence from a common ancestral gene
  • inhibits SLC9A8 gene expression through reducing its basal transcription, suggesting an important role of EGF in regulating SLC9A8 expression during intestinal maturation)
  • involved in nervous system development
  • EGF-induced cell migration is mediated by the lipase domain of PLCG1 and the subsequent IP(3) generation and intracellular calcium mobilization
  • promotes breast cancer tumour growth and survival, rapidly induces SERPINE1 expression in the breast adenocarcinoma cell line
  • crucial regulatory mechanism for EGF in GFER transcription within the promoter proximal region
  • IGF1 and epidermal growth factor (EGF) play important roles in the regulation of cell metabolism in response to different internal as well as external stimuli
  • may play a role in the function of the endocrine pancreas and in the pathogenesis of the diabetes mellitus
  • CELLULAR PROCESS cell life, differentiation
    signaling signal transduction
    a component
    small molecule metal binding,
  • Ca2+
  • protein
  • stimulating histone H3 phosphorylation,RSK2 dependent
  • rapidly depolymerizing actin and inducing formation of membrane ruffles
  • activating phospholipase D1b
  • cooperation between the EGF/EGFR and PTGES leads to a significant tumorigenic gain in epithelial cells
  • EGF controls the levels of CLDN2 and CLDN4 proteins and mRNAs through SRC and STAT3 activity
  • cell & other
  • protecting microtubules assembly of F-actin cytoskeleton and intestinal barrier integrity against oxidant injury, PRKZ dependent
    corresponding disease(s) HOMG4
    Susceptibility to extraaxial nervous system tumors
    Variant & Polymorphism other A61G polymorphism can be associated with susceptibility to development of extraaxial nervous system tumors but not with overall survival
    Candidate gene
    Therapy target