protein
| Eph receptor B6, EPHB6 ( |
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Eph receptor A4, EPHB4 ( |
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metabotropic glutamate receptor 1, mGlu1 ( |
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CD31 ( |
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ligand for Eph receptor tyrosine kinases, promoting sprouting behaviour and motility in the angiogenic endothelium  |
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its activation induces KDR internalization and activation, thereby controlling tip cell filopodial extension and vascular sprouting  |
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at the tip cell filopodia regulates the proper spatial activation of KDR endocytosis and signalling to direct filopodial extension  |
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EPHB4 interacts with its EFNB2 ligand to act as a bidirectional signaling system that mediates adhesion, migration, and guidance by controlling attractive and repulsive activities  |
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EFNB1 and EFNB2 interacted physically with IL7R  |
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NOTCH4 signaling controls EFNB2-induced endothelial progenitor cell dysfunction in preeclampsia  |
| ephrin-B2 knockout mice display defects in angiogenesis by both arteries and veins in the capillary networks of the head and yolk sac as well as in myocardial trabeculation ( | |
loss of the ephrinB2 cytoplasmic domain in mouse results in midgestation lethality ( |
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ephrinB2DeltaV mice expressing ephrinB2 lacking the C-terminal PDZ interaction site exhibited major lymphatic defects, including a failure to remodel their primary lymphatic capillary plexus into a hierarchical vessel network, hyperplasia, and lack of luminal valve formation ( |
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ephrinB2(5F/5F) mice, expressing ephrinB2 in which the five conserved tyrosine residues were replaced by phenylalanine to disrupt phosphotyrosine-dependent signaling events, displayed only a mild lymphatic phenotype ( |
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deletions of the gene reveal its essential roles for conduit vessel development in mice, suggesting similar functions during human vascular development and deregulation in vascular malformations ( |
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Efnb2(-/-) knockout show neuronal migration defects that recapitulate the ones observed in the neocortex, hippocampus and cerebellum of the reeler mouse ( |
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triple ephrin B1, B2, B3 knockouts knockout show neuronal migration defects that recapitulate the ones observed in the neocortex, hippocampus and cerebellum of the reeler mouse ( |