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FLASH GENE
Symbol EFNA5 contributors: mct/pgu - updated : 08-08-2014
HGNC name ephrin-A5
HGNC id 3225
Location 5q21      Physical location : 106.712.590 - 107.006.596
Synonym name eph-related receptor tyrosine kinase ligand 7
Synonym symbol(s) EPLG7, LERK7, AF1, EFL5, RAGS, GLC1M, AL-1
DNA
TYPE functioning gene
STRUCTURE 294.01 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
SLCO4C1 5q21.2 solute carrier organic anion transporter family, member 4C1 SLCO6A1 5q21.2 solute carrier organic anion transporter family, member 6A1 PAM 5q15 peptidylglycine alpha-amidating monooxygenase LOC134505 5q21.2 similar to eukaryotic translation initiation factor 3 subunit k; muscle specific gene FLJ20125 5q21.2 hypothetical protein FLJ20125 KIAA0433 5q21-q23 hypothetical protein FLJ20125 LOC90355 5q21.2 hypothetical gene supported by AF038182; BC009203 LOC345761 5q21.3 similar to 2610034M16Rik protein NUDT12 5q15 nudix (nucleoside diphosphate linked moiety X)-type motif 12 RAB9P1 5q14.3-q15 RAB9, member RAS oncogene family, pseudogene 1 LOC345571 5q21.3 similar to rap2 interacting protein x LOC391817 5 similar to protease (prosome, macropain) 26S subunit, ATPase 1 EFNA5 5q21 ephrin-A5 LOC391818 5 similar to Ubiquitin carboxyl-terminal hydrolase 7 (Ubiquitin thiolesterase 7) (Ubiquitin-specific processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus associated ubiquitin-specific protease) LOC345576 5q21.3 similar to Ubiquitin carboxyl-terminal hydrolase 7 (Ubiquitin thiolesterase 7) (Ubiquitin-specific processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus associated ubiquitin-specific protease) FBXO13 5q21.3 F-box only protein 13 RPS20P3 5q13-q23 ribosomal protein S20 pseudogene 3 FER 5q21 fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) GJA1P1 5q21.3 gap junction protein, alpha 1, 43kDa (connexin 43) pseudogene 1 PJA2 5q21.1 praja 2, RING-H2 motif containing LOC391819 5 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) MAN2A1 5q21-q22 mannosidase, alpha, class 2A, member 1 LOC153778 5q22.1 hypothetical LOC153778 LOC255338 5q22.1 hypothetical LOC255338 LOC91137 5q22.2 hypothetical protein BC017169 LOC134433 5q22.2 similar to Zinc finger DHHC domain containing protein 8 (Zinc finger protein 378) LOC285639 5q22.2 similar to Bcl-2-associated transcription factor TSLP 5q22.2 thymic stromal lymphopoietin TA-WDRP 5q22.2 T-cell activation WD repeat protein LOC133744 5q22.2 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 CAMK4 5q21-q23 calcium/calmodulin-dependent protein kinase IV STARD4 5q21.3 START domain containing 4, sterol regulated C5orf13 5q22.1 chromosome 5 open reading frame 13 TIGA1 5q21-q22 TIGA1 EPB41L4A 5q22.1 erythrocyte membrane protein band 4.1 like 4A FLJ11235 5q22.2 hypothetical protein FLJ11235 APC 5q21-q22 adenomatosis polyposis coli
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 5335 - 228 - 2005 15901737
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Hearing/Equilibriumearinner  highly
Reproductivefemale systembreastmammary gland highly
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivecartilage  moderately Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • GPI anchored, membrane protein
  • HOMOLOGY
    Homologene
    FAMILY
  • ephrin family
  • CATEGORY signaling , receptor membrane tyrosine kinase
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • involved in short-range contact-mediated axonal guidance
  • signaling within caveola-like domains and leading to increased adhesion of cells as fibronectin in an beta 1 integrin dependent manner
  • tyrosine kinase receptor may be stimulating axon fasciculation
  • EFNA2, EFNA3, EFNA5, and neural activity act together to control patterning of eye-specific retinogeniculate layers
  • acted as a tumor suppressor in glioma, and its negative regulation of EGFR contributed to the suppressive effect
  • may be actors in the guidance of dopaminergic projections
  • plays a key role in lens fiber cell shape and cell–cell interactions
  • EFNA5-EPHA4/EPHA5 system plays an important role in the direct pathway-dependent regulation of the substantia nigra pars reticulata in both acute and adaptive cocaine responses
  • up-regulated in the reorganizing cortex after stroke during the time period of axonal sprouting
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    EFNA5 and EPHA5 signals play a necessary, activity-independent role in the initiation of the early phases of synaptogenesis
  • EFNA5 signaling regulates axonal sprouting and functional recovery after stroke
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPHA7
  • binds to the receptor tyrosine kinases EPHA2, EPHA3 and EPHB1
  • ligand of the Eph receptor tyrosine kinases
  • interaction with EPHA2 (disruption in EPHA2–EFNA5 interaction leads to the internalization of N-cadherin and a disruption in the binding of N-cadherin with beta-catenin)
  • EFNA5 interaction with the EPHA5 receptor following neuron-neuron contact during early development of hippocampus induces a complex program of synaptogenic events
  • RHEB and EFNA5 come together at the lysosome to activate MTOR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia
    tumoral     --low  
    down-regulation in chondrosarcomas compared with normal cartilage
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS