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FLASH GENE
Symbol EFNA5 contributors: mct/pgu - updated : 08-08-2016
HGNC name ephrin-A5
HGNC id 3225
Location 5q21      Physical location : 106.712.590 - 107.006.596
Synonym name eph-related receptor tyrosine kinase ligand 7
Synonym symbol(s) EPLG7, LERK7, AF1, EFL5, RAGS, GLC1M, AL-1
DNA
TYPE functioning gene
STRUCTURE 294.01 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 5335 - 228 - 2005 15901737
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Hearing/Equilibriumearinner  highly
Reproductivefemale systembreastmammary gland highly
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivecartilage  moderately Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • GPI anchored, membrane protein
  • HOMOLOGY
    Homologene
    FAMILY
  • ephrin family
  • CATEGORY signaling , receptor membrane tyrosine kinase
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • involved in short-range contact-mediated axonal guidance
  • signaling within caveola-like domains and leading to increased adhesion of cells as fibronectin in an beta 1 integrin dependent manner
  • tyrosine kinase receptor may be stimulating axon fasciculation
  • EFNA2, EFNA3, EFNA5, and neural activity act together to control patterning of eye-specific retinogeniculate layers
  • acted as a tumor suppressor in glioma, and its negative regulation of EGFR contributed to the suppressive effect
  • may be actors in the guidance of dopaminergic projections
  • plays a key role in lens fiber cell shape and cell–cell interactions
  • EFNA5-EPHA4/EPHA5 system plays an important role in the direct pathway-dependent regulation of the substantia nigra pars reticulata in both acute and adaptive cocaine responses
  • up-regulated in the reorganizing cortex after stroke during the time period of axonal sprouting
  • EPHA2 and EFNA5 participate likely in the complex, global patterning of lens fiber cells that is necessary for maximal optical quality
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    EFNA5 and EPHA5 signals play a necessary, activity-independent role in the initiation of the early phases of synaptogenesis
  • EFNA5 signaling regulates axonal sprouting and functional recovery after stroke
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPHA7
  • binds to the receptor tyrosine kinases EPHA2, EPHA3 and EPHB1
  • ligand of the Eph receptor tyrosine kinases
  • interaction with EPHA2 (disruption in EPHA2–EFNA5 interaction leads to the internalization of N-cadherin and a disruption in the binding of N-cadherin with beta-catenin)
  • EFNA5 interaction with the EPHA5 receptor following neuron-neuron contact during early development of hippocampus induces a complex program of synaptogenic events
  • RHEB and EFNA5 come together at the lysosome to activate MTOR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia
    tumoral     --low  
    down-regulation in chondrosarcomas compared with normal cartilage
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS