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FLASH GENE
Symbol EEPD1 contributors: mct - updated : 29-08-2018
HGNC name endonuclease/exonuclease/phosphatase family domain containing 1
HGNC id 22223
Location 7p14.2      Physical location : 36.192.835 - 36.341.151
Synonym name
  • KIAA1706 protein
  • hypothetical protein LOC80820
  • Synonym symbol(s) KIAA1706, HSPC107
    DNA
    TYPE functioning gene
    STRUCTURE 148.32 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 4687 62 569 - 2017 28082258
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     stomach   highly
    Respiratoryrespiratory tractlarynx  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • genome stability during replication stress is maintained by EEPD1, which initiates HR and inhibits classical non-homologous end-joining (cNHEJ) and micro-homology mediated end joining (MMEJ)
  • HR protein EEPD1 maintains genome stability during embryonic replication stress
  • EEPD1 performs a gatekeeper function for replication fork repair by mediating the fork cleavage that permits initiation of HR-mediated repair and restart of stressed forks
  • EEPD1 cleavage of stressed replication forks may result in a toxic intermediate when replication fork repair cannot be completed
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • EEPD1 is a novel NR1H2, NR1H3-regulated gene in macrophages and likely it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS