basic FUNCTION
| genome stability during replication stress is maintained by EEPD1, which initiates HR and inhibits classical non-homologous end-joining (cNHEJ) and micro-homology mediated end joining (MMEJ) |
|
HR protein EEPD1 maintains genome stability during embryonic replication stress |
|
EEPD1 performs a gatekeeper function for replication fork repair by mediating the fork cleavage that permits initiation of HR-mediated repair and restart of stressed forks |
|
EEPD1 cleavage of stressed replication forks may result in a toxic intermediate when replication fork repair cannot be completed |