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FLASH GENE
Symbol EEF2K contributors: mct - updated : 28-08-2014
HGNC name eukaryotic elongation factor-2 kinase
HGNC id 24615
Location 16p12.1      Physical location : 22.217.591 - 22.300.065
Synonym name elongation factor 2 kinase
EC.number 2.7.1.-
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 80.00 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveintestinesmall intestine  highly
 intestinelarge intestinecolon highly
 mouthtongue  predominantly
Lymphoid/Immunelymph node   highly
 spleen   highly
Reproductivefemale systembreastmammary gland highly
 female systemplacenta  moderately
 female systemuteruscervix highly
 male systemprostate  highly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
Muscular    
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal conserved region homologous to the catalytic domain of myosin heavy chain kinase A (MHCKA)
  • C terminal EEF2 targeting domain (repeat of 36 aa, motif 36)
  • conjugated PhosphoP
    mono polymer heteromer , monomer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Eef2k
    ortholog to murine Eef2k
    Homologene
    FAMILY eukaryotic protein kinase superfamily
    CATEGORY enzyme , regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • regulator of EEF2
  • involved in the regulation of protein synthesis
  • regulates dendritic spine stability and synaptic structure by modulating activity-dependent dendritic BDNF synthesis
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • EEF2K/EEF2 pathway is a key biochemical sensor that couple neuronal activity to spine plasticity, by controlling the dendritic translation of BDNF
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ATP
  • Ca2+
  • protein
  • calmodulin
  • inactivation of EEF2K by CDK1 may serve to keep EEF2 active during mitosis (where calcium levels rise) and thereby permit protein synthesis to proceed in mitotic cells
  • upon activation, EEF2K phosphorylates and thereby inhibits EEF2, resulting in a dramatic reduction of mRNA translation
  • cell & other
    REGULATION
    Other undergoes calcium/calmodulin-dependent intramolecular autophosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in several forms of malignancy
    Susceptibility
    Variant & Polymorphism
    Candidate gene for anticancer drugs
    Marker
    Therapy target
    ANIMAL & CELL MODELS