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FLASH GENE
Symbol EEF2K contributors: mct - updated : 28-08-2014
HGNC name eukaryotic elongation factor-2 kinase
HGNC id 24615
Location 16p12.1      Physical location : 22.217.591 - 22.300.065
Synonym name elongation factor 2 kinase
EC.number 2.7.1.-
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 80.00 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ20274 16p13.11 hypothetical protein FLJ20274 SAH 16p13.11 SA hypertension-associated homolog (rat) MGC16943 16p13.11 similar to RIKEN cDNA 4933424N09 gene LOC81691 16p13.11 exonuclease NEF-sp MGC48972 16p13.11 hypothetical protein MGC48972 LOC57149 16p11.2 hypothetical protein A-211C6.1 FLJ23558 16p13.11-p12.3 hypothetical protein FLJ23558 DNAH3 16p12 dynein, axonemal, heavy polypeptide 3 LOC57146 16p12 promethin ZP2 16p12.2 zona pellucida glycoprotein 2 (sperm receptor) FLJ38819 16p12.3 hypothetical protein FLJ38819 CRYM 16p13.11-p12.3 crystallin, mu LOC388220 16 LOC388220 LOC92267 16p12.3 similar to FLJ12363 protein LOC388221 16 similar to nuclear pore complex interacting protein LOC388222 16 similar to MGC9515 protein LOC388223 16 similar to KIAA0220 IMAA 16p12 hLAT1-3TM LOC388224 16 similar to carbonic anhydrase VA, mitochondrial precursor; carbonic anhydrase V, mitochondrial; carbonic dehydratase DREV1 16p13-p12 DORA reverse strand protein 1 IGSF6 16p13-p12 immunoglobulin superfamily, member 6 OTOA 16p12.12 otoancorin LOC94431 16p12.3 similar to RNA polymerase I transcription factor RRN3 LOC390681 16 similar to RNA polymerase I transcription factor RRN3 MGC9515 16p12.3 hypothetical protein MGC9515 LOC390682 16 similar to PI-3-kinase-related kinase SMG-1 isoform 1; lambda/iota protein kinase C-interacting protein; phosphatidylinositol 3-kinase-related protein kinase LOC342293 16p12.3 similar to hypothetical protein UQCRC2 16p12.2 ubiquinol-cytochrome c reductase core protein II MGC50721 16p12.3 hypothetical protein MGC50721 LOC146174 16p12.3 hypothetical protein LOC146174 LOC146177 16p12.3 hypothetical protein LOC146177 LOC390683 16 similar to NAD(P) dependent steroid dehydrogenase-like EEF2K 16p12.1-q12.2 similar to NAD(P) dependent steroid dehydrogenase-like RPC5 16p12.3 RNA polymerase III 80 kDa subunit RPC5 CDR2 16p12.2 cerebellar degeneration-related protein 2, 62kDa LOC390684 16 similar to RRN3 LOC283846 16p12.3 PI-3-kinase-related kinase SMG-1-like LOC388225 16 similar to MGC9515 protein HS3ST2 16p12 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 KIAA1203 16p12.3 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 SCNN1G 16p12.2-p12.1 sodium channel, nonvoltage-gated 1, gamma SCNN1B 16p12.2-p12.1 sodium channel, nonvoltage-gated 1, beta (Liddle syndrome) COG7 16p11.2 component of oligomeric golgi complex 7 GGA2 16p12 golgi associated, gamma adaptin ear containing, ARF binding protein 2
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveintestinesmall intestine  highly
 intestinelarge intestinecolon highly
 mouthtongue  predominantly
Lymphoid/Immunelymph node   highly
 spleen   highly
Reproductivefemale systembreastmammary gland highly
 female systemplacenta  moderately
 female systemuteruscervix highly
 male systemprostate  highly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
Muscular    
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal conserved region homologous to the catalytic domain of myosin heavy chain kinase A (MHCKA)
  • C terminal EEF2 targeting domain (repeat of 36 aa, motif 36)
  • conjugated PhosphoP
    mono polymer heteromer , monomer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Eef2k
    ortholog to murine Eef2k
    Homologene
    FAMILY eukaryotic protein kinase superfamily
    CATEGORY enzyme , regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • regulator of EEF2
  • involved in the regulation of protein synthesis
  • regulates dendritic spine stability and synaptic structure by modulating activity-dependent dendritic BDNF synthesis
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • EEF2K/EEF2 pathway is a key biochemical sensor that couple neuronal activity to spine plasticity, by controlling the dendritic translation of BDNF
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ATP
  • Ca2+
  • protein
  • calmodulin
  • inactivation of EEF2K by CDK1 may serve to keep EEF2 active during mitosis (where calcium levels rise) and thereby permit protein synthesis to proceed in mitotic cells
  • upon activation, EEF2K phosphorylates and thereby inhibits EEF2, resulting in a dramatic reduction of mRNA translation
  • cell & other
    REGULATION
    Other undergoes calcium/calmodulin-dependent intramolecular autophosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in several forms of malignancy
    Susceptibility
    Variant & Polymorphism
    Candidate gene for anticancer drugs
    Marker
    Therapy target
    ANIMAL & CELL MODELS