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FLASH GENE
Symbol EEF1D contributors: mct - updated : 08-04-2014
HGNC name eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
HGNC id 3211
Location 8q24.3      Physical location : 144.661.866 - 144.679.845
Synonym name
  • guanine nucleotide exchange protein
  • antigen NY-CO-4
  • deltaEF1
  • Synonym symbol(s) EF-1D, FLJ20897, FP1047
    DNA
    TYPE functioning gene
    STRUCTURE 17.98 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    HHCM 8q24.3 Mahlavu hepatocellular carcinoma LY6H 8q24.3 lymphocyte antigen 6 complex, locus H LOC338328 8q24.3 high density lipoprotein-binding protein FLJ38705 8q24.3 hypothetical protein FLJ38705 GLI4 8q24.3 GLI-Kruppel family member GLI4 FLJ14129 8q24.3 hypothetical protein FLJ14129 LOC389691 8 LOC389691 TOP1MT 8q24.3 LOC389691 MGC3113 8q24 hypothetical protein MGC3113 RHPN1 8q24.3 rhophilin, Rho GTPase binding protein 1 LOC389692 KIAA0150 8q24.3 rhophilin, Rho GTPase binding protein 1 LOC389693 8 LOC389693 FLJ12150 8q24.3 hypothetical protein FLJ12150 LOC389694 8 similar to FLJ46354 protein PP3856 8q24.3 similar to CG3714 gene product EEF1D 13q12 eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) TIGD5 8q24.3 tigger transposable element derived 5 FLJ13852 8q24.3 hypothetical protein FLJ13852 TSTA3 8q24.3 tissue specific transplantation antigen P35B KIAA0628 8q24.3 tissue specific transplantation antigen P35B LOC286075 8q24.3 hypothetical protein LOC286075 LOC286076 8q24.3 similar to hypothetical protein ERK8  extracellular signal-regulated kinase 8 FLJ46072 8q24.3 FLJ46072 protein LOC389695 8 LOC389695 LOC389696 8 LOC389696 LOC286080 8q24.3 similar to CG3104-PA SCRIB 8q24.3 similar to CG3104-PA SIAHBP1 8q24.2-qtel similar to CG3104-PA LOC340371 8q24.3 hypothetical protein LOC340371 LOC389697 8 similar to epiplakin LOC392274 8 similar to cDNA sequence BC024139 PLEC1 8q24 plectin 1, intermediate filament binding protein 500kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2497 71.42 647 - 2002 11829477
  • encoding for the longest product
  • 8 splicing 1276 30.99 281 - 2002 11829477
  • an 8 exons variant
  • lacking exons 2 & 3
  • encoding for the shortest product
  • 8 - 1219 - 262 - 2002 11829477
    7 - 1204 - 257 - 2002 11829477
    9 - 1452 - 281 - 2002 11829477
    10 - 2381 - 647 - 2002 11829477
    8 - 1458 - 281 - 2002 11829477
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
     stomach   highly
    Endocrinepancreas   moderately
    Lymphoid/Immunetonsils   predominantly
    Reproductivefemale systembreastmammary gland highly
     female systemovary  highly
     male systemprostate  moderately
    Respiratorylung   moderately
    Skin/Tegumentskin   highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularstriatumskeletal moderately
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an eukaryotic elongation factor 1 (EF-1) guanine nucleotide exchange domain
  • a conserved consensus phosphorylation site for the mitotic cyclin-dependent kinase 1 required for its posttranslational modification during mitosis, resulting in lower affinity to its substrate EEF1A
  • HOMOLOGY
    interspecies homolog to rattus Eef1d (87.15 pc)
    homolog to murine Eef1d (85.47 pc)
    intraspecies homolog to EEF1B
    Homologene
    FAMILY
  • EF-1-beta/EF-1-delta family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • having translation factor activity and involved in proline biosynthesis
  • encoding a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome
  • plays a key role in mediating BMP6-induced transcriptional activation of CDH1 in breast cancer cells
  • is likely the switch through which BMP6 restores CDH1-mediated cell-to-cell adhesion and prevents breast cancer metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component 4 subunits: alpha, beta, delta, and gamma
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HIV-1 Tat
  • TPT1
  • SIAH1-interacting protein and EFF1D functions as a novel negative regulator of SIAH1
  • CSNK2A1 substrate for CSNK2A1 phosphorylation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancerous compared to noncancerous oesophageal tissues, and correlated with lymph node metastases, advanced disease stages and poorer prognosis in oesophageal carcinoma
    tumoral     --over  
    in medulloblastoma is adversely associated with with adverse outcome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS