basic FUNCTION
| promoting the transfer of aminoacylated tRNA to the A site of the ribosome |
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oncogenicity of eEF1A2 may be related either to its role in protein synthesis or to potential non-canonical functions |
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regulates oncogenesis through AKT1 and PI3K-dependent cytoskeletal remodeling |
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might play an important role in pancreatic carcinogenesis, possibly by acting as a tumour oncogene |
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important role for EEF1A2 in driving cap-independent translation of utrophin A in skeletal muscle |
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PI4KB, EEF1A2 and PI(4)P likely play an important role in mammary neoplasia and acinar development |
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is involved in protein synthesis, suppression of apoptosis, and regulation of actin function and cytoskeletal structure |
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plays an important role in prostate cancer development, especially in inhibiting apoptosis |
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both EEF1A1 and EEF1A2 colocalise with all EEF1B2 subunits, in such close proximity that they are highly likely to be in a complex |
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stimulates the phospholipid signaling and activates the AKT1 -dependent cell migration and actin remodeling that ultimately favors tumorigenesis |
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EEF1A1, and EEF1A2 proteins play a critical role in numerous human diseases through enhancement of oncogenesis, blockade of apoptosis, and increased viral pathogenesis |