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FLASH GENE
Symbol EEF1A1 contributors: mct/npt/pgu - updated : 28-03-2015
HGNC name eukaryotic translation elongation factor 1 alpha 1
HGNC id 3189
Location 6q13      Physical location : 74.225.474 - 74.230.755
Synonym name
  • leukocyte receptor cluster (LRC) member 7
  • elongation factor 1 A-1
  • elongation factor Tu
  • glucocorticoid receptor AF-1 specific elongation factor
  • prostate tumor-inducing protein 1
  • cervical cancer suppressor 3
  • Synonym symbol(s) EEF-1, EEF1A, EF-Tu, EF1A1, GRAF-1EF, LENG7, PTI1, eEF1A-1, CCS3, FLJ25721, MGC131894, MGC16224, GR-EF
    DNA
    TYPE functioning gene
    STRUCTURE 5.28 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC340167 6q14.1 similar to hypothetical protein DKFZp434A1315 KCNQ5 6q14 potassium voltage-gated channel, KQT-like subfamily, member 5 C6orf148 6q13 chromosome 6 open reading frame 148 EIF3S6P1 6q13 eukaryotic translation initiation factor 3, subunit 6 48kDa pseudogene 1 LOC391942 6 similar to syntenin-2alpha LOC391943 6 similar to Multifunctional protein ADE2 LOC340168 6q14.1 similar to developmental pluripotency associated 5; embryonal stem cell specific gene 1 LOC154288 6q14.1 similar to RIKEN cDNA 2410004A20 RPL39P3 6q14.1 ribosomal protein L39 pseudogene 3 DDX43 6q12-q13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 C6orf150 6q13 chromosome 6 open reading frame 150 MTO1 6q14.1 mitochondrial translation optimization 1 homolog (S. cerevisiae) EEF1A1 6q14 eukaryotic translation elongation factor 1 alpha 1 LOC389411 6 LOC389411 SLC17A5 6q14-q15 solute carrier family 17 (anion/sugar transporter), member 5 CD109 6q14.1 CD109 antigen (Gov platelet alloantigens)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3528 50 462 - 2003 12853148
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrain   highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three GTP- efTU binding motifs
  • 5' TOP sequence may be an important core-promoter element
  • C-terminus interacting with PASK
  • mono polymer complex
    HOMOLOGY
    intraspecies paralog to EEF1A2
    Homologene
    FAMILY
  • GTP-binding elongation factor family
  • EF-Tu/EF-1A subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus
    text exported from the nucleus with tRNA
    basic FUNCTION
  • eukaryotic translation elongation factor 1, alpha 1, binding aminoacyl tRNAs to 80S ribosomes
  • GTP-binding protein
  • may have a potential tumor suppressor activity mediated by its interaction with ZBTB16
  • both EEF1A1 and EEF1A2 colocalise with all EEF1B2 subunits, in such close proximity that they are highly likely to be in a complex
  • modulates cytoskeleton, exhibits chaperone-like activity and also controls cell proliferation and cell death
  • EEF1A1, and EEF1A2 proteins play a critical role in numerous human diseases through enhancement of oncogenesis, blockade of apoptosis, and increased viral pathogenesis
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • elongation factor 1 complex
  • INTERACTION
    DNA
    RNA
    small molecule
  • GTP
  • protein
  • interacting with EEF, beta subunit to exchange bound GDP to GTP
  • exportin 5 binding EEFA1 and tRNA, thereby mediating export from nucleus
  • interacting with the BTB domain of ZBTB16
  • interacting with SPHK1 and SPHK2
  • interaction partner of PASK (interaction between the PAS A and kinase domains of PASKIN and to the C-terminus of EEF1A1)
  • interaction with DLC1 (contribution of the SAM-EEF1A1 interaction as a potentially important GAP-independent modulation of cell migration by DLC1)
  • interaction between LRRK2 and EEF1A1 and EEF1A2 may reciprocally modulate their physiological function
  • interaction between IFIT1 and eukaryotic elongation factor-1A (EEF1A1)
  • interacts with and directly activates SPHK1
  • interactions of AICDA with EEF1A1 and heat-shock protein 90 kD (HSP90AA1) are inversely correlated
  • possibility that SUGT1 competes with viral RNA for binding to EEF1A1
  • UBD stabilizes the translation elongation factor EEF1A1 which contributes to cancer cell proliferation
  • EEF1AKNMT-catalyzed EEF1A1 methylation increases EEF1A1 intrinsic GTPase activity in vitro and protein production in cells
  • cell & other
    REGULATION
    Phosphorylated by TGFBR1 (TGFBR1 is a novel regulatory mechanism that provides a direct link to regulation of protein synthesis by TGFB as an important component in the TGFB-dependent regulation of protein synthesis and cell proliferation)
    Other negatively regulated by FMR1 protein in brain
    regulation of EEF1A1 by PASKIN-dependent phosphorylation in somatic as well as in sperm cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS