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FLASH GENE
Symbol EED contributors: mct - updated : 02-12-2014
HGNC name embryonic ectoderm development
HGNC id 3188
Location 11q14.2      Physical location : 85.955.814 - 85.989.778
Synonym name WD protein associating with integrin cytoplasmic tails 1
Synonym symbol(s) HEED, WAIT1
DNA
TYPE functioning gene
STRUCTURE 33.97 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC390228 11 hypothetical gene supported by AK058145 RAB30 11q12-q14 RAB30, member RAS oncogene family PCF11 11q13 pre-mRNA cleavage complex II protein Pcf11 DKFZp547G183 11q13.5 hypothetical protein DKFZp547G183 FLJ37874 11q13.5-q14.1 hypothetical protein FLJ37874 MDS025 11q14.1 hypothetical protein MDS025 HCP28 11q14.1 cytochrome c, somatic pseudogene FLJ37266 11q14.1 hypothetical protein FLJ37266 DLG2 11q21 discs, large homolog 2, chapsyn-110 (Drosophila) LOC390229 11 similar to HNRPC protein LOC143548 11q14.1 similar to REST corepressor HT007 11q14.1 uncharacterized hypothalamus protein HT007 DKFZp586C1924 11q14.1 hypothetical protein DKFZp586C1924 ZF 11q14 HCF-binding transcription factor Zhangfei FLJ38159 11q14.1 hypothetical protein FLJ38159 SYTL2 11q14 synaptotagmin-like 2 MGC34732 11q14.1 hypothetical protein MGC34732 PICALM 11q14 phosphatidylinositol binding clathrin assembly protein LOC283226 11q14.1 similar to Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit (CAAX farnesyltransferase alpha subunit) (Ras proteins prenyltransferase alpha) (FTase-alpha) (Type I protein geranyl-geranyltransferase alpha sub EED 11q14.2-q22.3 embryonic ectoderm development HSPC138 11q14.1 hypothetical protein HSPC138 LOC387796 11 LOC387796 FLJ23514 11q14.1 hypothetical protein FLJ23514 ME3 11q21 malic enzyme 3, NADP(+)-dependent, mitochondrial LOC387797 11 LOC387797 SPUVE 11q14.1 protease, serine, 23 OR7E13P 11q13-q14.3 olfactory receptor, family 7, subfamily E, member 13 pseudogene OR7E2P 11q13-q14 olfactory receptor, family 7, subfamily E, member 2 pseudogene FZD4 11q14.2 frizzled homolog 4 (Drosophila) FLJ22104 11q14.1 hypothetical protein FLJ22104 RAB38 11q14 RAB38, member RAS oncogene family CTSC 11q21 cathepsin C LOC390230 11 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) GRM5 11q13-q13.4 glutamate receptor, metabotropic 5 TYR 11q14.3 tyrosinase (oculocutaneous albinism IA) NOX4 11q14.2-q21 NADPH oxidase 4 PSMAL/GC
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2006 50.07 441 - 2008 18302803
11 - 2413 45.4 400 - 2008 18302803
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestineileum highly Homo sapiens
 liver   highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a small N-terminal domain (AAs 1–80)
  • a potential PEST sequence
  • a bipartite nuclear localization signal (NLS)
  • C-terminal domain, which is common to the four EED isoforms, contains seven repeats of a canonical WD-40 motif, may be folded as a seven-bladed beta-propeller protein , specifically binding to histone tails carrying trimethyl-lysine residues associated with repressive chromatin marks, and that this leads to the allosteric activation of the methyltransferase activity of PRC2
  • WD40 domain is a methyllysine histone-binding domain
  • HOMOLOGY
    interspecies homolog to murine embryonic ectoderm development (eed)
    homolog to Drosophila extra sex comb (polycomb-group PcG)
    Homologene
    FAMILY
  • WD repeat ESC family
  • Polycomb group proteins superfamily
  • CATEGORY adhesion , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • shuttle between the nucleus and the cytosol
  • basic FUNCTION
  • negative regulation of homeotic gene
  • polycomb group protein playing a role in the early stages of virus infection
  • together with RACK1, may define a novel subfamily of WD repeat proteins that interact with distinct subsets of integrin cytoplasmic tails and may act as specific regulators of integrin function
  • exerted an antiviral activity at the late stage of HIV-1 replication, which included genomic RNA packaging and virus assembly, resulting possibly from a mistrafficking of viral genomic RNA (gRNA) or gRNA/Gag complex
  • physically and functionally couples TNFRSF1A to SMPD3
  • both EED and SUZ12 are required for the integrity of PRC2 and PRC2-mediated H3K27 methylation
  • the unique ability of EED to bind multiple histone marks, which leads to distinct outcomes, may play a pivotal role in controlling the activity of PRC2 and its function in propagating and spreading repressive histone marks in the nucleus
  • mediates the repression of gene activity through histone deacetylation, and it may act as a specific regulator of integrin function
  • integral role for EED as an epigenetic exchange factor coordinating the activities of PRC1 and 2
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text embryomic development
    PATHWAY
    metabolism
    signaling
    a component
  • recruited to the TNFRSF1A•NSMAF•RACK1-complex
  • component of a novel PHF1-EZH2 complex and demonstrate its important role in H3K27 methylation and Hox gene silencing
  • part of PRC2 complex containing four core components: EZH2, EED, SUZ12, and RBBP7
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with EZH2, HDAC proteins and involved in transcriptional repression through this interaction MA, beta-integrin
  • additional major player in the regulation of XIST expression
  • interacting with PPP1R8 (only interacted with full-length EED, whereas two EED interaction domains were mapped to the central and C-terminal thirds of PPP1R8)
  • interaction partner of SMPD3
  • interacts with EZH2, SUZ12 and RBBP4 to form the polycomb repressive complex 2 (PRC2), which functions to initiate epigenetic silencing of genes involved in cell fate decisions
  • PINK1 associated with EED/WAIT1 in cells and relocated EED/WAIT1 to the mitochondria
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to ulcerative colitis (UC)
    Variant & Polymorphism other
  • g.-1850G>C polymorphism in the EED gene might be associated with the susceptibility to UC
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS