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FLASH GENE
Symbol EED contributors: mct - updated : 02-12-2016
HGNC name embryonic ectoderm development
HGNC id 3188
Corresponding disease
COGIS Cohen-Gibson syndrome
Location 11q14.2      Physical location : 85.955.814 - 85.989.778
Synonym name WD protein associating with integrin cytoplasmic tails 1
Synonym symbol(s) HEED, WAIT1
DNA
TYPE functioning gene
STRUCTURE 33.97 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2006 50.07 441 - 2008 18302803
11 - 2413 45.4 400 - 2008 18302803
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestineileum highly Homo sapiens
 liver   highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a small N-terminal domain (AAs 1–80)
  • a potential PEST sequence
  • a bipartite nuclear localization signal (NLS)
  • C-terminal domain, which is common to the four EED isoforms, contains seven repeats of a canonical WD-40 motif, may be folded as a seven-bladed beta-propeller protein , specifically binding to histone tails carrying trimethyl-lysine residues associated with repressive chromatin marks, and that this leads to the allosteric activation of the methyltransferase activity of PRC2
  • WD40 domain is a methyllysine histone-binding domain
    • HOMOLOGY
    interspecies homolog to murine embryonic ectoderm development (eed)
    homolog to Drosophila extra sex comb (polycomb-group PcG)
    Homologene
    FAMILY
  • WD repeat ESC family
  • Polycomb group proteins superfamily
    • CATEGORY adhesion , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • shuttle between the nucleus and the cytosol
    • basic FUNCTION
  • negative regulation of homeotic gene
  • polycomb group protein playing a role in the early stages of virus infection
  • together with RACK1, may define a novel subfamily of WD repeat proteins that interact with distinct subsets of integrin cytoplasmic tails and may act as specific regulators of integrin function
  • exerted an antiviral activity at the late stage of HIV-1 replication, which included genomic RNA packaging and virus assembly, resulting possibly from a mistrafficking of viral genomic RNA (gRNA) or gRNA/Gag complex
  • physically and functionally couples TNFRSF1A to SMPD3
  • both EED and SUZ12 are required for the integrity of PRC2 and PRC2-mediated H3K27 methylation
  • the unique ability of EED to bind multiple histone marks, which leads to distinct outcomes, may play a pivotal role in controlling the activity of PRC2 and its function in propagating and spreading repressive histone marks in the nucleus
  • mediates the repression of gene activity through histone deacetylation, and it may act as a specific regulator of integrin function
  • integral role for EED as an epigenetic exchange factor coordinating the activities of PRC1 and 2
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text embryomic development
    PATHWAY
    metabolism
    signaling
    a component
  • recruited to the TNFRSF1A•NSMAF•RACK1-complex
  • component of a novel PHF1-EZH2 complex and demonstrate its important role in H3K27 methylation and Hox gene silencing
  • part of PRC2 complex containing four core components: EZH2, EED, SUZ12, and RBBP7
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with EZH2, HDAC proteins and involved in transcriptional repression through this interaction MA, beta-integrin
  • additional major player in the regulation of XIST expression
  • interacting with PPP1R8 (only interacted with full-length EED, whereas two EED interaction domains were mapped to the central and C-terminal thirds of PPP1R8)
  • interaction partner of SMPD3
  • interacts with EZH2, SUZ12 and RBBP4 to form the polycomb repressive complex 2 (PRC2), which functions to initiate epigenetic silencing of genes involved in cell fate decisions
  • PINK1 associated with EED/WAIT1 in cells and relocated EED/WAIT1 to the mitochondria
  • GLRX3 interacts with embryonic ectoderm development (EED), a Polycomb Group (PcG) protein that serves as a core component of the Polycomb repressive complex 2 (PRC2) and contributes to the regulation of chromatin remodeling and cell differentiation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) COGIS
    Susceptibility to ulcerative colitis (UC)
    Variant & Polymorphism other
  • g.-1850G>C polymorphism in the EED gene might be associated with the susceptibility to UC
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS