Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | EDN2 | contributors: mct - updated : 19-03-2014 |
HGNC name | endothelin 2 |
HGNC id | 3177 |
|
Location | 1p34.2 Physical location : 41.944.448 - 41.950.344 |
Synonym name | preproendothelin 2 |
Synonym symbol(s) | ET2, PPET2 |
DNA |
TYPE | functioning gene |
STRUCTURE | 5.90 kb 5 Exon(s) |
Genomic sequence alignment details |
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10 Kb 5' upstream gene genomic sequence study |
MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
tissue |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
physiological period | embryo |
Text | in the later stages of embryonic development in mouse |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
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isoforms | Precursor | prepro VIC cleaved to Big Vic including a VIC-like peptide, then releasing mature VIC (EDN2) |
HOMOLOGY |
interspecies | homolog to rattus Edn2 (68.0pc) |
homolog to murine Edn2 (68.8pc) |
Homologene |
FAMILY |
CATEGORY | signaling |
SUBCELLULAR LOCALIZATION | extracellular |
text | secreted protein |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
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a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility | for essential hypertension |
Variant & Polymorphism other | the EDN2 A985 allele may be a risk factor for atrial fibrillation in patients with hypertrophic cardiomyopathy (Nagai 2007) |
Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |
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