| basic FUNCTION
| endothelin 1, vaso-constrictor/pressor peptide |
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phospholipase C activator, playing a role in airways, including bronchoconstriction, airway mucus secretion, cell proliferation, and inflammation |
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playing a role on epithelial ion transport in airways |
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playing a direct role in HDL metabolism |
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endothelial cell-derived vasoconstrictor and growth factor |
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potent vasoactive peptide that is synthesized and released by the vascular endothelium and is a marker of endothelial function  |
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induces cortical neurite elongation through the endothelin A receptor |
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may exert its vasoconstrictive effects in part by targeting KCNK3 |
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induces mRNA and protein secretion of CCL2 and IL6, forming an autocrine signaling pathway that stimulates collagen accumulation in the extracellular matrix |
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increases collagen deposition in the extracellular matrix by inducing an autocrine signaling loop involving secretion of CCL2 and IL6 |
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increases CCL2 and IL6 mRNAs and peptide secretion in mesangial cells |
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role of EDN1 in linking TLR7 inflammatory signaling to subsequent fibrosis |
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TGFbeta-induced EDN1 expression in dermal fibroblasts and showed that the TGFB1-induced expression of profibrotic genes was dependent on EDN1 |
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in part because it induces the unfolded protein response in pulmonary artery smooth muscle cells, triggers proinflammatory processes that likely contribute to vascular remodeling in pulmonary hypertension |
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BMPs act upstream and in parallel to EDN1 to promote ventral fates in the arches during early dorsal-ventral patterning |
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would act in a cooperative manner with EDN2, giving to the villus the straight enough to withstand mechanical stress |
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potent vasoconstrictor, the production of which is mainly catalyzed by endothelin-converting enzymes ( |
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is a potent lymphangiogenic factor that relies on the interplay with hypoxic microenvironment and with VEGFA, VEGFC, and FIGF |
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induces positive inotropy (enhanced contractility) in cardiac muscle |
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EDN1 affects systolic Ca2+, and myofilament Ca2+ sensitivity and PRKCE is the upstream kinase involved in all of these intracellular regulatory processes |
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integral role for ectoderm-derived EDN1 in early arch morphogenesis, particularly in the intermediate domain ( |
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essential role of endothelin 1 (EDN1) signaling through the endothelin receptor type A (EDNRA) in patterning the mandibular portion of the first pharyngeal arch |
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RETN and EDN1 have been reported to inhibit adipogenesis and regulate adipocyte insulin resistance, respectively |
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EDN1 activation of EDNRA signalled through ARF6, which is crucial for lipolysis |
