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FLASH GENE
Symbol EDEM3 contributors: - updated : 18-12-2006
HGNC name ER degradation enhancer, mannosidase alpha-like 3
HGNC id 16787
Location 1q25      Physical location : 184.659.626 - 184.724.041
Synonym name chromosome 1 open reading frame 22
Synonym symbol(s) C1orf22
DNA
TYPE functioning gene
STRUCTURE 64.00 kb     20 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Reproductivemale systemprostate   
Respiratorylung    
 respiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Class I alpha-mannosidases (glycosyl hydrolase family 47) in its N-terminal domain
  • a protease-associated motif in its C-terminal region
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Edem3
    ortholog to murine Edem3
    Homologene
    FAMILY glycosyl hydrolase 47 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • alpha1,2-mannosidases activity
  • enhancing endoplasmic reticulum-associated degradation (ERAD)
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS