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FLASH GENE
Symbol EDC4 contributors: mct - updated : 07-02-2014
HGNC name enhancer of mRNA decapping 4
HGNC id 17157
Location 16q22.1      Physical location : 67.906.998 - 67.918.405
Synonym name
  • autoantigen Ge-1
  • autoantigen RCD-8
  • human enhancer of decapping large subunit
  • Synonym symbol(s) Ge-1, RCD-8, HEDLS
    DNA
    TYPE functioning gene
    STRUCTURE 11.00 kb     29 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    29 - 4739 152 1401 - 1997 9067524
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  predominantly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemplacenta  moderately
     female systemuterus  lowly
     male systemtestis  lowly
    Respiratoryrespiratory tractlarynx  moderately
    Skin/Tegumentskin   moderately
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • an N-terminal WD40-repeat domain connected by a low-complexity region to a conserved C-terminal domain
  • a central serine-rich region
  • a putative hydrophilic nuclear localization sequence (NLS) near its C terminus, and the C-terminal domain interacts with DCP2 and mediates EDC4 oligomerization and P-body localization
  • HOMOLOGY
    Homologene
    FAMILY
  • Ge-1 protein family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • may be a target of human autoantibodies
  • bridging the interaction between DCP1 and DCP2
  • might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • COASY/EDC4 complex formation is regulated by growth factors and is affected by cellular stresses
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PATL1 interacting with DCP2/DCP1A, LSM1/LSM4, EDC4, and EDC3
  • interacts with and regulates the dephospho-CoA kinase activity of CoA synthase
  • XRN1 directly interacts with EDC4 and ACE
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS