SUBCELLULAR LOCALIZATION
| plasma membrane,junction,tight
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| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus
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| text
| its localization defines the stage-specific changes in actin cortex organization critical for accurate cell division  |
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concentrates at the equatorial membrane during cytokinesis in live cells |
| basic FUNCTION
| putative regulator of the Ras-related Rho subfamily of GTP binding proteins |
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having a critical role in Rho activation during cytokinesis |
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expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis |
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concentrates on the central spindle by binding to central spindlin |
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having function in polar lamellipodia formation and polarity maintenance during "contractile ring-independent" cytokinesis in adherent cells |
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can, in a dose-dependent manner, reduce multinucleation induced by GRLF1, and GRLF1 has opposing roles in regulating cytokinesis |
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plays a critical role in RHOA, RHOB activation during cytokinesis, and thus may play a role in the pathogenesis of pancreatic cancer |
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plays a role in cytokinesis, in which it regulates local activation of RHOA together with ECT2 |
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PKP4 and ECT2 are transported via distinct motors, identifying a novel pathway implicating KIF3B in the regulation of actin organization during cytokinesis |
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guanine nucleotide exchange factor for Rho family GTPases, that links the PRKCI-PARD6A complex to RAC1 activation and cellular transformation |
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with PRKCI, are genetically and functionally linked in non-small cell lung cancer, acting to coordinately drive tumor cell proliferation and invasion through formation of an oncogenic PRKCI-PARD6A-ECT2 complex |
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nuclear guanine nucleotide exchange factors ECT2 and NET1 regulate RhoB-mediated cell death after DNA damage |
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an ANLN-ECT2 complex stabilizes central spindle microtubules at the cortex during cytokinesis |
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contributes to tight junction function in epithelial cells |
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is important for tight junction function and maintenance of cell polarity |
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is a central regulator of mitotic rounding, thus uncovering a link between the cell-cycle machinery that drives mitotic entry and its accompanying actin remodeling C |
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is a RhoGEF that plays a well-established role in formation of the actomyosin contractile ring at mitotic exit, through the local activation of RHOA |
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negatively regulates the Wingless/Wnt signaling pathway, and is a human proto-oncogene |
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cell cycle regulator that plays critical roles in cytokinesis |
