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FLASH GENE
Symbol ECE2 contributors: mct - updated : 17-06-2013
HGNC name endothelin converting enzyme 2
HGNC id 13275
Location 3q27.1      Physical location : 183.967.444 - 184.010.818
Synonym symbol(s) KIAA0604, ECE-2
EC.number 3.4.24.71
DNA
TYPE functioning gene
STRUCTURE 43.37 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text alternative promoter and splicing
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 3498 - 883 - 2010 20807771
ECE2-A
- - 3162 - 736 - 2010 20807771
an intracytoplasmic tail, a transmembrane domain and a large extracellular domain
3 - 1027 - 255 - 2010 20807771
ECE2-C
- - 3387 - 811 - 2010 20807771
- - 3249 86.3 765 - 2010 20807771
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrineadrenal gland    
 neuroendocrine    
Nervousbraindiencephalonamygdala  
 braindiencephalonhypothalamus  
Reproductivefemale systemovary   
 male systemprostate   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye,lens retina foveal, macular, RPE, choroid eye anterior segment
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a transmembrane domain
conjugated MetalloP
HOMOLOGY
intraspecies homolog to ECE1
Homologene
FAMILY ECE-1 family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic,vesicle
basic FUNCTION
  • converting big endothelin-1 to endothelin-1
  • is able to process endoproteolytically peptides intermediates to generate biologically active peptides
  • membrane-bound zinc-dependent metalloprotease, displaying an acidic pH optimum characteristic of maturing enzymes acting late in the secretory pathway
  • exhibits restricted neuroendocrine distribution, intracellular localization, and an acidic pH optimum (
  • potential role for ECE2 in the non-classical processing of spinal cord peptides and morphine responses (
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • components of the endothelin system, are EDN1, EDNRB and ECE1
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+, Cu2+, Co2+, Ni2+ binding
    protein
    cell & other
    REGULATION
    activated by Co2+
    Cu2+ and Zn2+ at low concentration
    inhibited by Cu2+ and Zn2+ at high concentration
    Ni2+
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    by amyloid-beta (APP), and its expression elevated in Alzheimer disease postmortem brain tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS