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FLASH GENE
Symbol ECD contributors: mct - updated : 23-10-2013
HGNC name ecdysoneless homolog (Drosophila)
HGNC id 17029
Location 10q22.2      Physical location : 74.894.282 - 74.927.853
Synonym name
  • suppressor of S. cerevisiae gcr2
  • ecdysoneless homolog
  • protein SGT1
  • suppressor of GCR2
  • Synonym symbol(s) HSGT1, GCR2, SGT1
    DNA
    TYPE functioning gene
    STRUCTURE 33.57 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2151 - 601 - -
    14 - 2280 - 644 - -
    15 - 2379 - 677 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a transactivation activity in its C-terminal region
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • localizes to both nucleus and cytoplasm and shuttles between the nucleus and cytoplasm, but it exhibits strong nuclear export
  • basic FUNCTION
  • transcriptional activator
  • altered ECD levels and/or function may potentially contribute to oncogenesis
  • plays a role in cell cycle progression via the RB-E2F pathway
  • functioning as a transcriptional regulator
  • tumor-promoting factor that is differentially expressed in pancreatic cancer and potentially regulates glucose metabolism within cancer cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    putative regulator of glycolitic gene expression
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulator of TP53 stability and function
  • interacts with EP300, a histone acetyltransferase, and coexpression of ECD with EP300 enhances the ECD-mediated transactivation activity
  • TXNIP interacts with ECD and decreases MDM2-mediated TP53 ubiquitination, leading to TP53 stabilization and an increase in TP53 activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS