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FLASH GENE
Symbol EBNA1BP2 contributors: mct/npt - updated : 10-04-2009
HGNC name EBNA1 binding protein 2
HGNC id 15531
Location 1p34.2      Physical location : 43.629.845 - 43.638.241
Synonym name
  • nuclear FGF3 binding protein
  • nucleolar protein p40; homolog of yeast EBNA1-binding protein
  • nuclear FGF3 binding protein
  • Synonym symbol(s) P40, EBP2, NOBP
    DNA
    TYPE functioning gene
    STRUCTURE 8.08 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC47816 1p34.1 hypothetical protein MGC47816 ZMYND12 1p34.1 zinc finger, MYND domain containing 12 FLJ11838 1p34.1 hypothetical protein FLJ11838 FLJ20972 1p34.1 hypothetical protein FLJ20972 TMSL1 1 thymosin-like 1 PPIH 1p34.1 peptidyl prolyl isomerase H (cyclophilin H) NSEP1 1p34 nuclease sensitive element binding protein 1 CLDN19 1p33-34.2 claudin 19 LEPRE1 1p34.1 leucine proline-enriched proteoglycan (leprecan) 1 MGC955 1p34.1 hypothetical protein MGC955 LOC388624 1 LOC388624 ERMAP 1p34.1 erythroblast membrane-associated protein LOC51058 1p34.1 hypothetical protein LOC51058 LOC391032 1 similar to EVIN1; expressed in activated T/LAK lymphocytes LOC391033 1 similar to Makorin 1 LOC343515 1p34.1 similar to ATPase, H+ transporting, lysosomal 31kD, V1 subunit E isoform 1; V-ATPase, subunit E; H(+)-transporting two-sector ATPase, 31kDa subunit; H+-transporting ATP synthase chain E, vacuolar; vacuolar proton pump, 31-kd subunit SLC2A1 1p35-p31.3 solute carrier family 2 (facilitated glucose transporter), member 1 EBNA1BP2 1p35-p33 EBNA1 binding protein 2 FLJ32000 1p34.1 hypothetical protein FLJ32000 LOC256339 1p34.1 similar to ENSANGP00000010412 MGC17299 1p34.1 hypothetical protein MGC17299 MGC52423 1p34.1 hypothetical protein MGC52423 TIE 1p34 tyrosine kinase with immunoglobulin and epidermal growth factor homology domains CDC20 9q13-q21 CDC20 cell division cycle 20 homolog (S. cerevisiae) MPL 1p34 myeloproliferative leukemia virus oncogene ELOVL1 1p34.1 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 MED8 1p34.1 mediator of RNA polymerase II transcription, subunit 8 homolog (yeast) LOC388625 1 similar to FLJ00408 protein HT036 1p34.1 hypothetical protein HT036 PTPRF 1p34 protein tyrosine phosphatase, receptor type, F JMJD2 1p34.1 jumonji domain containing 2 SIAT6 1p34.1 sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase) ARTN 1p32-p31.3 artemin IPO13 1p34.1 importin 13 DPH2L2 1p34 diptheria toxin resistance protein required for diphthamide biosynthesis-like 2 (S. cerevisiae)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1397 34.7 306 - Kapoor (2005)
    - - 1514 - 361 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Skin/Tegumentskin    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple transmembrane segments
  • a cobalt transport protein domain
  • HOMOLOGY
    interspecies homolog to murine Ebp2
    ortholog to yeast S. pombe ebp2
    Homologene
    FAMILY
  • EBP2 family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text
  • nucleolar envelope
  • nucleolar retention is dependent on the presence of nucleostemin in the nucleolus (Romanova 2009)
  • basic FUNCTION
  • may be functioning in a dynamic scaffold for ribosome biogenesis (Hirano 2009)
  • plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases (Kapoor 2005)
  • acts like a pseudosubstrate that directly recruits Fbw7 to nucleoli
  • CELLULAR PROCESS nucleotide
    PHYSIOLOGICAL PROCESS
    text 275 pre-rRNA processing
    PATHWAY
    metabolism
    signaling
    a component
  • part of the large protein complex containing proteins related to pre-rRNA processing, such as PES1, DDX21, and GNL3, in addition to several ribosomal proteins (Romanova 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to EBNA1 and enables EBNA1 to partition EBV-based plasmids in saccharomyces cerevisiae (Kapoor 2005)
  • interacting with AURKB (role for this kinase in enabling EBNA1BP2 binding to mitotic chromosomes, suggesting that this kinase can regulate EBV segregation) (Kapoor 2005)
  • critical nucleolar factor that directly mediates FBXW7 nucleolar targeting
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS