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FLASH GENE
Symbol EBI3 contributors: mct - updated : 30-04-2011
HGNC name Epstein-Barr virus induced gene 3
HGNC id 3129
Location 19p13.3      Physical location : 4.229.539 - 4.237.517
Synonym name
  • IL-27 subunit beta
  • cytokine receptor; epstein-Barr virus
  • Synonym symbol(s) IL-27B, IL27B
    DNA
    TYPE functioning gene
    STRUCTURE 7.99 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    TJP3 19p13.3 tight junction protein 3 (zona occludens 3) APBA3 19p13.3 amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2) MRPL54 19p13.3 mitochondrial ribosomal protein L54 MGC15631 19p13.3 hypothetical protein MGC15631 MATK 19p13.3 megakaryocyte-associated tyrosine kinase KIAA1086 19p13.3 megakaryocyte-associated tyrosine kinase LOC388494 19 hypothetical gene supported by AL365406; BC034005 ATCAY 19p13.3 ataxia, cerebellar, Cayman type (caytaxin) ITGB1BP3 19p13.3 integrin beta 1 binding protein 3 DAPK3 19p13.3 death-associated protein kinase 3 EEF2 19p13.3 eukaryotic translation elongation factor 2 PIASY 19p13.3 protein inhibitor of activated STAT protein PIASy LOC387622 19 hypothetical gene supported by NM_020224 FBI1 MAP2K2 7q32 mitogen-activated protein kinase kinase 2 CREB3L3 19p13.3 cAMP responsive element binding protein 3-like 3 SIRT6 19p13.3 sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) KIAA1981 EBI3 19p13.3 Epstein-Barr virus induced gene 3 FLJ10374 19p13.3 hypothetical protein FLJ10374 SHD 19p13.3 src homology 2 domain-containing transforming protein D MGC23244 19p13.3 hypothetical protein MGC23244 FSD1 19p13.3 fibronectin type 3 and SPRY (spla, ryanodine) domain containing (with coiled-coil motif) 1 STAP2 19p13.3 signal-transducing adaptor protein-2 FLJ14981 19p13.3 hypothetical protein FLJ14981 SH3GL1 19p13.3 SH3-domain GRB2-like 1 CHAF1A 19p13.3 chromatin assembly factor 1, subunit A (p150) UBXD1 19p13 UBX domain containing 1 MGC2641 19p13.3 hepatoma-derived growth factor-related protein 2 FLJ20700 19p13.3 hypothetical protein FLJ20700 LOC388495 19 similar to Calphotin CG4795-PA LRG SEMA6B 19p13.3 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B MGC17791 19p13.3 hypothetical protein MGC17791
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1149 - 229 - 1996 8551575
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Lymphoid/Immunetonsils    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion secreted
    at STAGE
    physiological period pregnancy
    Text placenta,syncytiotrophoblasts
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    two potential N glycosylation sites,fibronectin type III domain,signal peptide,two pairs of conserved cysteine residues and LSDWS motif
    conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to interleukin 12p40 subunit
    Homologene
    FAMILY hematopoietin receptor family
    CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • playing a role in regulated cell-mediated immune responses
  • negatively regulates the expression of IL17, IL22 and RORC as well as protective immunity against L. monocytogenes
  • possible role in atherogenesis (
  • . may play an inhibitory role in allergic asthma development
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text cell-mediated,immune response
    PATHWAY
    metabolism
    signaling
    a component part of heterodimer composed of a cytokine subunit, IL27, and a soluble receptor, Epstein–Barr virus (EBV)-induced gene 3 (EBI3)
    INTERACTION
    DNA
    RNA
    small molecule
    protein calnexin and 60kDa cytoplasmic protein (SRSTM1) in the endoplasmic reticulum when newly synthesized
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS