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FLASH GENE
Symbol EBF4 contributors: mct/npt - updated : 17-03-2010
HGNC name early B-cell factor 4
HGNC id 29278
Location 20p13      Physical location : 2.673.523 - 2.740.753
Synonym name
  • KIAA1442 protein
  • Olf-1/EBF-like 4
  • transcription factor COE4
  • Synonym symbol(s) KIAA1442, COE4, RP5-860F19.3, O/E-4
    DNA
    TYPE functioning gene
    STRUCTURE 67.23 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 2931 - 598 - Wang (2002)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   moderately
    Reproductivefemale systemovary  highly
     female systembreastmammary gland moderately
     male systemprostate  moderately
    Respiratorylung   predominantly
     respiratory tractlarynx  highly
    Visualeye   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • zinc-finger
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Ebf4
    ortholog to murine Ebf3
    Homologene
    FAMILY
  • COE family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a activator of transcription
  • keystone in the regulatory network that coordinates B cell lineage specification and commitment (Lukin 2008)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • forming either a homodimer or a heterodimer with a related family member
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS