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FLASH GENE
Symbol EBF2 contributors: mct/npt - updated : 03-03-2017
HGNC name early B-cell factor 2
HGNC id 19090
Location 8p21.2      Physical location : 25.701.572 - 25.902.392
Synonym name
  • OLF-1/EBF-LIKE 3
  • Collier, Olf and EBF 2
  • transcription factor COE2
  • metencephalon-mesencephalnon-olfactory transcription factor 1
  • Synonym symbol(s) FLJ11500, COE2, OE-3, EBF-2, O/E-3
    DNA
    TYPE functioning gene
    STRUCTURE 200.82 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2297 - 575 - Nusbaum (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivestomach    
    Respiratoryrespiratory tracttrachea   
     respiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmature hematopoietic
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • Olf/EBF family of helix-loop-helix transcription factors
  • COE family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • olfactory gene regulator
  • recognizes variations of the palindromic sequence
  • 5'-ATTCCCNNGGGAATT-3'
  • keystone in the regulatory network that coordinates B cell lineage specification and commitment (Lukin 2008)
  • both EBF2 and EBF3, singly or together, control the migration of Cajal-Retzius (CR) cells arising in the cortical hem, and Ebfs directly regulate CR cell development
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text olfactory neurodevelopment
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • FOXG1 binds to mammalian-specific noncoding sequences to repress over 12 transcription factors expressed in early progenitors, including EBF2/3, DMRT3, DMRTA1, and EYA2
  • DPF3 is a direct transcriptional target of EBF2 in brown adipocytes, thereby establishing a regulatory module through which EBF2 activates and also recruits DPF3-anchored BAF complexes to chromatin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS