Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EBF2 contributors: mct/npt - updated : 03-03-2017
HGNC name early B-cell factor 2
HGNC id 19090
Location 8p21.2      Physical location : 25.701.572 - 25.902.392
Synonym name
  • OLF-1/EBF-LIKE 3
  • Collier, Olf and EBF 2
  • transcription factor COE2
  • metencephalon-mesencephalnon-olfactory transcription factor 1
  • Synonym symbol(s) FLJ11500, COE2, OE-3, EBF-2, O/E-3
    DNA
    TYPE functioning gene
    STRUCTURE 200.82 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MSCP 8p21.2 mitochondrial solute carrier protein PRO1496 8p21.2 hypothetical protein PRO1496 LOC389642 8 LOC389642 NKX3-1 8p21 NK3 transcription factor related, locus 1 (Drosophila) LOC137814 8p21.2 similar to homeobox protein NKX2-6 STC1 8p21-p11.2 stanniocalcin 1 ADAM28 8p21.3-p12 a disintegrin and metalloproteinase domain 28 ADAMDEC1 8p21.1 ADAM-like, decysin 1 ADAM7 8p21.2 a disintegrin and metalloproteinase domain 7 NEF3 8p22-p21 neurofilament 3 (150kDa medium) NEFL 8p21 neurofilament, light polypeptide 68kDa LOC286061 8p21.2 hypothetical protein LOC286061 DOCK5 8p21.2 dedicator of cytokinesis 5 GNRH1 8p21-p12 gonadotropin-releasing hormone 1 (leutinizing-releasing hormone) KCTD9 8p21.1 potassium channel tetramerisation domain containing 9 CDCA2 8p12-21 cell division cycle associated 2 EBF2 8p21.1 early B-cell factor 2 PPP2R2A 8p21.1 protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform LOC157489 8p21.1 similar to hypothetical protein FLJ10498 BNIP3L 8p21 BCL2/adenovirus E1B 19kDa interacting protein 3-like PNMA2 8p21.1 paraneoplastic antigen MA2 LOC338097 8p21 proteasome activator subunit 2 pseudogene DPYSL2 8p21 dihydropyrimidinase-like 2 ADRA1A 8p21-p11.2 adrenergic, alpha-1A-, receptor LOC286129 8p21.1 similar to chromosome 15 open reading frame 2 STMN4 8P21.1 stathmin-like 4 TRIM35 8p21.1 tripartite motif-containing 35 PTK2B 8p21.1 PTK2B protein tyrosine kinase 2 beta CHRNA2 8p21 cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) EPHX2 8p21-p12 epoxide hydrolase 2, cytoplasmic GULOP 8p21.1 gulonolactone (L-) oxidase pseudogene CLU 8p21.3-p12 clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J) SCARA3 8p21 scavenger receptor class A, member 3 FLJ10853 8p21.1 hypothetical protein FLJ10853 LOC157570 8p21.1 hypothetical protein LOC157570 TOPK 8p21.2 hypothetical protein LOC157570 MGC45780 8p21.1 hypothetical protein MGC45780 LOC389643 8 hypothetical gene supported by AK129923 ELP3 8p21.1 elongation protein 3 homolog (S. cerevisiae)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2297 - 575 - Nusbaum (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivestomach    
    Respiratoryrespiratory tracttrachea   
     respiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmature hematopoietic
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • Olf/EBF family of helix-loop-helix transcription factors
  • COE family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • olfactory gene regulator
  • recognizes variations of the palindromic sequence
  • 5'-ATTCCCNNGGGAATT-3'
  • keystone in the regulatory network that coordinates B cell lineage specification and commitment (Lukin 2008)
  • both EBF2 and EBF3, singly or together, control the migration of Cajal-Retzius (CR) cells arising in the cortical hem, and Ebfs directly regulate CR cell development
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text olfactory neurodevelopment
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • FOXG1 binds to mammalian-specific noncoding sequences to repress over 12 transcription factors expressed in early progenitors, including EBF2/3, DMRT3, DMRTA1, and EYA2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS