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FLASH GENE
Symbol EBAG9 contributors: - updated : 01-03-2006
HGNC name estrogen receptor binding site associated, antigen, 9
HGNC id 3123
Location 8q23.3      Physical location : 110.551.928 - 110.577.389
Synonym name
  • cancer associated surface antigen
  • estrogen-receptor-binding fragment associated gene 9
  • receptor binding cancer antigen expressed on SiSo cells
  • receptor-binding cancer antigen expressed on SiSo cells
  • Synonym symbol(s) RCAS1, EB9
    DNA
    TYPE functioning gene
    STRUCTURE 24.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site   HRE
    text structure a palindromic estrogen response element (ERE) in the 5' utr
    MAPPING cloned Y linked N status confirmed
    Map see ANGPT1
    Physical map
    LOC346887 8q23.1 similar to hypothetical protein FLJ30794 OXR1 8q23 oxidation resistance 1 STARS 8q23.1 striated muscle activator of Rho-dependent signaling ANGPT1 8q22.3-q23 angiopoietin 1 MGC35555 8q23.1 hypothetical protein MGC35555 LOC389681 8 similar to nuclear receptor binding factor-2; comodulator of PPAR and RXR EIF3S6 8q22-q23 eukaryotic translation initiation factor 3, subunit 6 48kDa LOC392260 8 similar to dJ753D5.2 (novel protein similar to RPS17 (40S ribosomal protein S17)) KIAA0103 8q23.2 KIAA0103 FLJ30668 8q23.2 hypothetical protein FLJ30668 TRHR 8q23 thyrotropin-releasing hormone receptor CML66 8q23 chronic myelogenous leukemia tumor antigen 66 DC6 8q23.2 DC6 protein PKHD1L1 8q23.2 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 MAPK6PS5 8q23 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 EBAG9 8q23.3 estrogen receptor binding site associated, antigen, 9 FLJ20366 8q23.2 hypothetical protein FLJ20366 LOC392261 8 similar to hypothetical protein A930017M01 KCNV1 8q22.3-q24.1 potassium channel, subfamily V, member 1 LOC392262 8 similar to laminin-binding protein CSMD3 8q23.3 CUB and Sushi multiple domains 3
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   moderately
    Cardiovascularheart    
    Digestiveliver   moderately
    Nervousbrain   moderately
    Reproductivefemale systemovary   
     male systemtestis   
     male systemprostate   
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
  • breast cancer MCF-7
  • endometral carcinoma
  • fluid/secretion
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    coiled-coil domain necessary for the binding to the receptor
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Ebag9
    Homologene
    FAMILY
    CATEGORY antigen , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type III transmembrane protein with a Golgi-predominant localization
    basic FUNCTION
  • estrogen-responsive gene inhibiting cell growth
  • may be playing a role in endocrine-immune interactions in breast cancer
  • inducing growth arrest and apoptosis on activated immune cells, mediated by a putative death receptor
  • modulating surface expression of tumor-associated, normally cryptic O-linked glycan structures and contributing indirectly to the antigenicity of tumor cells
  • acting as a ligand for a putative receptor on immune cells such as peripheral lymphocytes and natural killer cells
  • may play important roles in epithelial ovarian cancer
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text inhibition of cell growth and apoptotic cell death
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with SNAPAP in the control on large dense-core vesicle zxocyosis
    cell & other
    REGULATION
    induced by estrogens
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non small cell lung carcinoma with poor prognosis, in squamous cell carcinoma of the oesophagus and in gallbladder cancer and ductal breast cancer in progression with poor prognosis
    tumoral     --over  
    in immune-mediated cholangitis,in primary biliary cirrhosis and in hepatocellular carcinoma with tumour dedifferentiation and increased proliferative activity
    tumoral     --over  
    in uterine endometrial cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS