basic FUNCTION
| repressing transcription from the E4 promoter in the absence of E1A |
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atypical ubiquitin E3 ligase, modulating its effector functions without promoting proteolysis |
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stimulating oligo-ubiquitylation in the hinge region of TP53 |
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mediating post-translational modification of TP53 |
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a key modulator of BMI1 activity in primitive hematopoietic cells |
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key player in the control of mammalian embryonic and somatic cell proliferation and survival |
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multifunctional protein involved in signaling pathways that play essential roles during normal development and tumorigenesis |
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multifunctional protein with transcriptional and atypical ubiquitin E3 ligase activities |
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involved in key signaling pathways commonly deregulated during cell transformation |
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role for E4F1 in the survival of myeloid leukemic cells |
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through its connection with the BMI1 and the CDKN2A/Arf-TPp53 axis, plays a role in stem cell–dependent skin homeostasis |