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FLASH GENE
Symbol E2F8 contributors: mct - updated : 15-03-2022
HGNC name E2F transcription factor 8
HGNC id 24727
Location 11p15.1      Physical location : 19.245.617 - 19.262.507
Synonym symbol(s) FLJ23311
DNA
TYPE functioning gene
STRUCTURE 16.00 kb     13 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3482 - 867 - 2020 32823614
13 - 3522 - 867 - 2020 32823614
13 - 3706 - 867 - 2020 32823614
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 mouth    
Lymphoid/Immunelymph node    
 thymus    
Reproductivefemale systemplacenta    Homo sapiens
 male systemtestis   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two distinct DNA-binding domains
  • absence of DP-dimerization, retinoblastoma-binding, and transcriptional activation domains
  • two DNA-binding domains (DBDs)
  • HOMOLOGY
    Homologene
    FAMILY E2F family of transcription factor
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • playing a crucial and well established role in cell cycle progression
  • having an important role in turning of the expression of E2F-target genes in the S-phase of the cell cycle
  • E2F8 contributes likly to the oncogenic potential of hepatocellular carcinoma (HCC)
  • E2F7 and E2F8 contain two DNA-binding domains (DBDs) and act as repressors
  • synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer
  • E2F7 and E2F8 act as tumor suppressors via transcriptional repression of genes involved in S-phase entry and progression
  • regulates the proliferation and invasion through epithelial-mesenchymal transition in cervical cancer
  • E2F8 and DLG2 regulate insulin secretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component can homodimerize with E2F7 (may have overlapping and perhaps synergistic roles in the control of cellular proliferation)
    INTERACTION
    DNA binds DNA without the requirement of co-factors such as DP1
    RNA
    small molecule
    protein
  • E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in lung cancer and is required for the growth of LC
    tumoral     --over  
    in human hepatocellular carcinoma (HCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    E2F8 is a novel therapeutic target for LC treatment
    cancerdigestiveliver
    may constitute a potential therapeutic target in hCC
    ANIMAL & CELL MODELS