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FLASH GENE
Symbol E2F7 contributors: mct - updated : 07-12-2001
HGNC name E2F transcription factor 7
HGNC id 23820
Location 12q21.1      Physical location : 77.415.026 - 77.459.360
DNA
TYPE functioning gene
STRUCTURE 45.00 kb     13 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuteruscervix  
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two DNA binding domains
HOMOLOGY
Homologene
FAMILY E2F family of transcription factors
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • playing an essential role in the regulation of cell cycle progression
  • regulating the expression of genes involved in cell cycle, DNA replication, DNA repair, and mitosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binds to the E2F DNA binding consensus site independently of DP co-factors
    RNA
    small molecule
    protein
  • unique repressor of a subset of E2F target genes whose products are required for cell cycle progression
  • TP53-dependent transcriptional up-regulation of its target, E2F7, leads to repression of relevant gene expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS