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FLASH GENE
Symbol E2F7 contributors: mct - updated : 07-12-2001
HGNC name E2F transcription factor 7
HGNC id 23820
Location 12q21.1      Physical location : 77.415.026 - 77.459.360
DNA
TYPE functioning gene
STRUCTURE 45.00 kb     13 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
VENTX2P3 12q15 VENT-like homeobox 2 pseudogene 3 LOC387869 12 LOC387869 LOC390343 12 similar to microtubule-associated proteins 1A/1B light chain 3 KCNC2 19q13.4 potassium voltage-gated channel, Shaw-related subfamily, member 2 CAPS2 12q21.1 calcyphosphine 2 MGC26856 12q21.1 hypothetical protein MGC26856 MGC39497 12q21.1 hypothetical protein MGC39497 GLIPR1 12q21.1 GLI pathogenesis-related 1 (glioma) HRB2 12q21.1 HIV-1 rev binding protein 2 LOC390344 12 similar to 6-phosphogluconate dehydrogenase, decarboxylating LOC390345 12 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) PHLDA1 12q15 pleckstrin homology-like domain, family A, member 1 NAP1L1 12q15 nucleosome assembly protein 1-like 1 LOC121071 12q21.1 similar to NOGO-interacting mitochondrial protein FLJ23560 12q21.1 hypothetical protein FLJ23560 OSBPL8 12q14 oxysterol binding protein-like 8 LOC123031 12q21.1 similar to 60S ribosomal protein L21 HIP14 12q14-q15 similar to 60S ribosomal protein L21 CSRP2 12q21.1 cysteine and glycine-rich protein 2 LOC390346 12 similar to Ran-specific GTPase-activating protein (Ran binding protein 1) (RanBP1) E2F7 12q21.1 E2F transcription factor 7 NAV3 12q21.1 neuron navigator 3 MRPL11P3 12q21.2 neuron navigator 3 LOC390347 12 similar to ras related v-ral simian leukemia viral oncogene homolog A SYT1 12q15-q21 synaptotagmin I LOC338756 12q21.2 similar to hypothetical protein PAWR 12q21.2-q21.32 PRKC, apoptosis, WT1, regulator PPP1R12A 12q15-q21 protein phosphatase 1, regulatory (inhibitor) subunit 12A LOC120872 12q21.2 similar to ribosomal protein L7 LOC283308 12q21.2 similar to 60S ribosomal protein L26 FLJ90579 12q21.2 hypothetical protein FLJ90579 LOC387870 12 similar to protein tyrosine phosphatase, receptor type, Q isoform 1 precursor; glomerular mesangial cell receptor protein-tyrosine phosphatase PTPRQ 12q21.2 protein tyrosine phosphatase, receptor type, Q MYF6 12q21 myogenic factor 6 (herculin) MYF5 12q21 myogenic factor 5 LIN7A 12q21 lin-7 homolog A (C. elegans) FLJ21963 12q21.31 FLJ21963 protein PPFIA2 12q21.31 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuteruscervix  
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two DNA binding domains
HOMOLOGY
Homologene
FAMILY E2F family of transcription factors
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • playing an essential role in the regulation of cell cycle progression
  • regulating the expression of genes involved in cell cycle, DNA replication, DNA repair, and mitosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binds to the E2F DNA binding consensus site independently of DP co-factors
    RNA
    small molecule
    protein
  • unique repressor of a subset of E2F target genes whose products are required for cell cycle progression
  • TP53-dependent transcriptional up-regulation of its target, E2F7, leads to repression of relevant gene expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS