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FLASH GENE
Symbol E2F5 contributors: mct/npt - updated : 05-04-2016
HGNC name E2F transcription factor 5, p130-binding
HGNC id 3119
Location 8q21.2      Physical location : 86.089.618 - 86.126.751
Synonym name transcription factor E2F5
Synonym symbol(s) E2F-5
DNA
TYPE functioning gene
STRUCTURE 37.13 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC392241 8 similar to tropomyosin 3, gamma LOC138046 8q21.13 hypothetical protein LOC138046 KIAA1764 8q21.13-q21.2 KIAA1764 protein E2F5 8q21.13 E2F transcription factor 5, p130-binding MGC59868 CA1 8q13-q22.1 carbonic anhydrase I CA3 8q13-q22.1 carbonic anhydrase III, muscle specific CA2 8q13-q22.1 carbonic anhydrase II LOC392242 8 hypothetical gene supported by NM_172239 GOR 8q21.2 exonuclease GOR LOC392243 8 hypothetical gene supported by NM_172239 LOC392244 8 hypothetical gene supported by NM_172239 LOC392245 8 hypothetical gene supported by NM_172239 LOC392246 8 hypothetical gene supported by NM_172239 LOC392247 8 hypothetical gene supported by NM_172239 LOC392248 8 similar to large subunit ribosomal protein L36a LOC392249 8 similar to 60S ribosomal protein L32 PSKH2 8q21.2 serine/threonine kinase PSKH2 ATP6V0D2 8q21.13 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 2 SLC7A13 8q21.2 solute carrier family 7, (cationic amino acid transporter, y  system) member 13 WWP1 8q21 solute carrier family 7, (cationic amino acid transporter, y  system) member 13 CGI-90 8q21.2 CGI-90 protein CPNE3 8q22.1-q22.2 copine III CNGB3 8q21-q22 cyclic nucleotide gated channel beta 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1740 - 345 - 2005 16172982
8 - 1594 - 185 - 2005 16172982
8 - 1743 37 346 - 2005 16172982
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunelymph node   highly
Reproductivemale systemprostate  highly
Respiratorylung   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine E2f5
intraspecies homolog to E2F4
Homologene
FAMILY
  • E2F/DP family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text down-regulated late in embryogenesis and this coincides with a change in its intracellular localization, from predominantly nuclear to cytoplasmic
    basic FUNCTION
  • acting to repress E2F-responsive genes, and having a strong capacity to inhibit transformation
  • could exert a strong influence over the susceptibility to oncogenic transformation
  • cell-cycle regulatory protein E2F5 might play a significant role in Ovarian epithelial cancer (OEC) pathogenesis
  • considered to act primarily as a transcriptional repressor in the cell cycle
  • E2F4 and E2F5 display overlapping roles in controlling the normal development of the male reproductive system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex MAD3/E2F4/E2F5/DP1/RBL1
  • linking the TGFB receptor to CMYC repression
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MADH3
  • E2F4
  • interacting with CENPF (CENPF translocation to the nucleus is an important first step during entry into quiescence)
  • by coopting E2F4, E2F5 regulation of cell cycle genes, MCIDAS drives massive centriole assembly in epithelial progenitors in a manner required for multiciliate cell differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    may be correlated with a worse prognosis of patients with esophageal squamous cell carcinoma (ESCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a novel potential candidate marker for malignant prostate carcinoma
  • Therapy target
    ANIMAL & CELL MODELS