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FLASH GENE
Symbol E2F5 contributors: mct/npt - updated : 05-04-2016
HGNC name E2F transcription factor 5, p130-binding
HGNC id 3119
Location 8q21.2      Physical location : 86.089.618 - 86.126.751
Synonym name transcription factor E2F5
Synonym symbol(s) E2F-5
DNA
TYPE functioning gene
STRUCTURE 37.13 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1740 - 345 - 2005 16172982
8 - 1594 - 185 - 2005 16172982
8 - 1743 37 346 - 2005 16172982
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunelymph node   highly
Reproductivemale systemprostate  highly
Respiratorylung   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine E2f5
intraspecies homolog to E2F4
Homologene
FAMILY
  • E2F/DP family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text down-regulated late in embryogenesis and this coincides with a change in its intracellular localization, from predominantly nuclear to cytoplasmic
    basic FUNCTION
  • acting to repress E2F-responsive genes, and having a strong capacity to inhibit transformation
  • could exert a strong influence over the susceptibility to oncogenic transformation
  • cell-cycle regulatory protein E2F5 might play a significant role in Ovarian epithelial cancer (OEC) pathogenesis
  • considered to act primarily as a transcriptional repressor in the cell cycle
  • E2F4 and E2F5 display overlapping roles in controlling the normal development of the male reproductive system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex MAD3/E2F4/E2F5/DP1/RBL1
  • linking the TGFB receptor to CMYC repression
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MADH3
  • E2F4
  • interacting with CENPF (CENPF translocation to the nucleus is an important first step during entry into quiescence)
  • by coopting E2F4, E2F5 regulation of cell cycle genes, MCIDAS drives massive centriole assembly in epithelial progenitors in a manner required for multiciliate cell differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    may be correlated with a worse prognosis of patients with esophageal squamous cell carcinoma (ESCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a novel potential candidate marker for malignant prostate carcinoma
  • Therapy target
    ANIMAL & CELL MODELS