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FLASH GENE
Symbol E2F3 contributors: mct/pgu - updated : 05-04-2016
HGNC name E2F transcription factor 3
HGNC id 3115
Location 6p22.3      Physical location : 20.402.136 - 20.493.945
Synonym symbol(s) RBBP3, RP1-177P22.2, E2F-3, KIAA0075, MGC104598, E2F3a, DKFZp686C18211,
DNA
TYPE functioning gene
STRUCTURE 91.81 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
RNPC6 6p22.3 RNA-binding region (RNP1, RRM) containing 6 CAP2 6p22.3 CAP, adenylate cyclase-associated protein, 2 (yeast) FAM8A1 6p23 family with sequence similarity 8, member A1 NUP153 6p25.3-p22.1 nucleoporin 153kDa KIF13A 6p23 kinesin family member 13A NHLRC1 6p22.3 NHL repeat containing 1 TPMT 6p22.3 thiopurine S-methyltransferase AOF1 6p22.3 amine oxidase, flavin containing 1 DEK 6p23 DEK oncogene (DNA binding) LOC391872 6 similar to ATP-dependent RNA helicase DDX18 (DEAD-box protein 18) (Myc-regulated DEAD-box protein) (MrDb) LOC391873 6 similar to inosine monophosphate dehydrogenase 1 isoform b; sWSS2608 IBRDC2 6p22.3 IBR domain containing 2 LOC346129 6p22.3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) ID4 6p23-p22.3 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein LOC391874 6 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) OACT1 6p22.3 O-acyltransferase (membrane bound) domain containing 1 E2F3 6q22 E2F transcription factor 3 PRO1051 6p22.2 hypothetical protein PRO1051 CDKAL1 6p22.2 CDK5 regulatory subunit associated protein 1-like 1 SOX4 6p22.3 SRY (sex determining region Y)-box 4 PRL 6p22.2-p22.1 prolactin PWWP1 6p22.2 PWWP domain containing 1 LOC389370 6 LOC389370 LOC391875 6 similar to 60S ribosomal protein L6 (TAX-responsive enhancer element binding protein 107) (TAXREB107) (Neoplasm-related protein C140) LOC346142 6p22.1 similar to hypothetical protein FLJ12671 LOC391876 6 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) VMP 6p21.33 vesicular membrane protein p24 DCDC2 6p22.1 doublecortin domain containing 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 5050 - 465 - 2009 19136625
  • e2F3a
  • - - - - - - 2009 19136625
  • also called E2F3b
  • required for myogenic differentiation, not depending on RB1
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a DNA binding domain
  • a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins
  • putative leucine zippers
  • a carboxyterminal domain of interaction with pRB
  • HOMOLOGY
    Homologene
    FAMILY
  • E2F/DP family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • controlling genes regulating S phase entry and DNA synthesis
  • involved in transcription repression in quiescent cell by interaction with histone deacetylase
  • playing a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses
  • could exert a strong influence over the susceptibility to oncogenic transformation
  • regulate cell cycle-dependent gene expression through opposing transcriptional activating and repressing activities in growing and quiescent cells
  • have a critical role in modifying cellular proliferation rate in bladder and prostate cancer
  • mediator of DNA damage-induced apoptosis
  • induces apoptosis in Hepatocellular carcinoma cells and plays important roles in regulating transcription
  • E2F3 is an oncogene with strong proliferative potential and is regularly dysregulated or overexpressed in cancer
  • in contrast to E2F1 and E2F3, which sensitize to death, E2F4 plays a crucial protective role in neuronal death evoked by DNA damage, hypoxia, and global ischemic insult
  • CELLULAR PROCESS cell cycle
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds specifically to RB1 protein, in a cell-cycle dependent manner
  • p107 (RBL1), p130 (RBL2) binding
  • modulates Aurora-A mRNA expression during the cell cycle (directly binds to Aurora-A promoter and stimulates the promoter activity)
  • with E2F1 contribute to ATM-dependent phosphorylation of TP53 and apoptosis in cells expressing E1A
  • HELLS interacts with E2F3A and cooperates with its oncogenic functions
  • PUM1 and PUM2 repress the translation of E2F3 by binding to the E2F3 3prime untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting microRNAs
  • TRIM28 has anti-proliferative activity in lung cancers via repression of E2F3, E2F4 that are critical for cell proliferation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in retinoblastoma
    tumoral     --over  
    and amplified in invasively growing bladder cancer
    tumoral     --over  
    inactivation of the RB1 pathway is required in addition to E2F3 overexpression in bladder tumours
    tumoral     --over  
    in liver cancer tissues
    tumoral     --over  
    of KIF14 and E2F3 protein in retinoblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    E2F3-Aurora-A axis could be an important target for cancer intervention
    ANIMAL & CELL MODELS